P2RY13

Purinergic receptor P2Y, G-protein coupled, 13
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2B6U​
Identifiers
Symbols	P2RY13 ; FKSG77; GPCR1; GPR86; GPR94; P2Y13; SP174
External IDs	OMIM: 606380 MGI: 1921441 HomoloGene: 12543 IUPHAR: 329 GeneCards: P2RY13 Gene
Gene ontology Molecular function • G-protein coupled purinergic nucleotide receptor activity Cellular component • endoplasmic reticulum • plasma membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • biological_process • G-protein coupled purinergic nucleotide receptor signaling pathway • cellular response to organic cyclic compound Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	53829	74191
Ensembl	ENSG00000181631	ENSMUSG00000036362
UniProt	Q9BPV8	Q9D8I2
RefSeq (mRNA)	NM_023914	NM_028808
RefSeq (protein)	NP_795713	NP_083084
Location (UCSC)	Chr 3: 151.33 – 151.33 Mb	Chr 3: 59.21 – 59.21 Mb
PubMed search

P2Y purinoceptor 13 is a protein that in humans is encoded by the P2RY13 gene.^[1][2][3]

The product of this gene, P2Y₁₃, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. Two transcript variants encoding the same protein have been identified for this gene.^[3]

See also

• P2Y receptor

References

1. Wittenberger T, Schaller HC, Hellebrand S (Mar 2001). "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors". J Mol Biol 307 (3): 799–813. doi:10.1006/jmbi.2001.4520. PMID 11273702.
2. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
3. "Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13".

External links

• "P2Y Receptors: P2Y₁₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Communi D, Gonzalez NS, Detheux M, et al. (2001). "Identification of a novel human ADP receptor coupled to G(i).". J. Biol. Chem. 276 (44): 41479–85. doi:10.1074/jbc.M105912200. PMID 11546776.
• Zhang FL, Luo L, Gustafson E, et al. (2002). "P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse.". J. Pharmacol. Exp. Ther. 301 (2): 705–13. doi:10.1124/jpet.301.2.705. PMID 11961076.
• Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fabre AC, Malaval C, Ben Addi A, et al. (2010). "P2Y13 receptor is critical for reverse cholesterol transport". Hepatology 52 (4): 1477–83. doi:10.1002/hep.23897. PMID 20830789.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.