FZD7

Frizzled class receptor 7
Identifiers
Symbols	FZD7 ; FzE3
External IDs	OMIM: 603410 MGI: 108570 HomoloGene: 20751 IUPHAR: 235 GeneCards: FZD7 Gene
Gene ontology Molecular function • G-protein coupled receptor activity • frizzled binding • protein binding • Wnt-protein binding • PDZ domain binding • Wnt-activated receptor activity Cellular component • plasma membrane • integral component of membrane Biological process • regulation of transcription, DNA-templated • G-protein coupled receptor signaling pathway • negative regulation of cell-substrate adhesion • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • stem cell maintenance • neuron differentiation • T cell differentiation in thymus • substrate adhesion-dependent cell spreading • regulation of catenin import into nucleus • non-canonical Wnt signaling pathway via JNK cascade • positive regulation of phosphorylation • negative regulation of ectodermal cell fate specification • positive regulation of transcription, DNA-templated • positive regulation of JNK cascade • somatic stem cell division • positive regulation of epithelial cell proliferation involved in wound healing • canonical Wnt signaling pathway • mesenchymal to epithelial transition • cellular response to retinoic acid Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8324	14369
Ensembl	ENSG00000155760	ENSMUSG00000041075
UniProt	O75084	Q61090
RefSeq (mRNA)	NM_003507	NM_008057
RefSeq (protein)	NP_003498	NP_032083
Location (UCSC)	Chr 2: 202.03 – 202.04 Mb	Chr 1: 59.48 – 59.49 Mb
PubMed search

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.^[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.^[3]

Interactions

FZD7 has been shown to interact with DLG4.^[4]

See also

• Frizzled

References

1. Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
2. Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
3. "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)".
4. Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. (Netherlands) 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714.

External links

• "Frizzled Receptors: FZD₇". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Finch PW, He X, Kelley MJ; et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap". Oncogene 23 (36): 6023–30. doi:10.1038/sj.onc.1207817. PMID 15195140.
• Omoto S, Hayashi T, Kitahara K; et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vincan E, Darcy PK, Smyth MJ; et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth". Differentiation 73 (4): 142–53. doi:10.1111/j.1432-0436.2005.00015.x. PMID 15901282.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Vincan E, Darcy PK, Farrelly CA; et al. (2007). "Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids". Oncogene 26 (16): 2340–52. doi:10.1038/sj.onc.1210026. PMID 17016432.
• Struewing IT, Barnett CD, Zhang W; et al. (2007). "Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1". Exp. Cell Res. 313 (16): 3526–41. doi:10.1016/j.yexcr.2007.07.012. PMID 17716656.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.