Cysteinyl leukotriene receptor 2

cysteinyl leukotriene receptor 2
Identifiers
Aliases	CYSLTR2, CYSLT2, CYSLT2R, HG57, HPN321, KPG_011, hGPCR21, GPCR21, PSEC0146
External IDs	MGI: MGI:1917336 HomoloGene: 10688 GeneCards: 57105
Gene ontology Molecular function • cysteinyl leukotriene receptor activity • G-protein coupled peptide receptor activity • leukotriene receptor activity Cellular component • integral component of plasma membrane • plasma membrane Biological process • positive regulation of cell death • neuropeptide signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • positive regulation of angiogenesis • immune response • leukotriene signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57105	70086
Ensembl	ENSG00000152207	ENSMUSG00000033470
UniProt	Q9NS75	Q920A1
RefSeq (mRNA)	NM_020377 NM_001308465 NM_001308467 NM_001308468 NM_001308469 NM_001308470 NM_001308471 NM_001308476	NM_001162412 NM_133720 XM_011245178
RefSeq (protein)	NP_001295394.1 NP_001295396.1 NP_001295397.1 NP_001295398.1 NP_001295399.1 NP_001295400.1 NP_001295405.1 NP_065110.1	NP_001155884.1 NP_598481.2 XP_011243480.1
Location (UCSC)	Chr 13: 48.65 – 48.71 Mb	Chr 14: 73.03 – 73.05 Mb
PubMed search
Wikidata

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Cysteinyl leukotriene receptor 2 is a protein that in humans is encoded by the CYSLTR2 gene.^[1][2][3]

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems.^[3]

See also

• Eicosanoid receptor

References

1. Takasaki J, Kamohara M, Matsumoto M, Saito T, Sugimoto T, Ohishi T, Ishii H, Ota T, Nishikawa T, Kawai Y, Masuho Y, Isogai T, Suzuki Y, Sugano S, Furuichi K (Aug 2000). "The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor". Biochem Biophys Res Commun 274 (2): 316–22. doi:10.1006/bbrc.2000.3140. PMID 10913337.
2. Van Keer C, Kersters K, De Ley J (Sep 1976). "L-Sorbose metabolism in Agrobacterium tumefaciens". Antonie Van Leeuwenhoek 42 (1–2): 13–24. doi:10.1007/BF00399445. PMID 1085123.
3. "Entrez Gene: CYSLTR2 cysteinyl leukotriene receptor 2".

External links

• "Leukotriene Receptors: CysLT₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Nothacker HP, Wang Z, Zhu Y; et al. (2001). "Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist". Mol. Pharmacol. 58 (6): 1601–8. PMID 11093801.
• Mita H, Hasegawa M, Saito H, Akiyama K (2002). "Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils". Clin. Exp. Allergy 31 (11): 1714–23. doi:10.1046/j.1365-2222.2001.01184.x. PMID 11696047.
• Takeda S, Kadowaki S, Haga T; et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
• Shirasaki H, Kanaizumi E, Watanabe K; et al. (2003). "Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa". Clin. Exp. Allergy 32 (7): 1007–12. doi:10.1046/j.1365-2222.2002.01425.x. PMID 12100046.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sjöström M, Johansson AS, Schröder O; et al. (2004). "Dominant expression of the CysLT2 receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells". Arterioscler. Thromb. Vasc. Biol. 23 (8): e37–41. doi:10.1161/01.ATV.0000082689.46538.DF. PMID 12816881.
• Mellor EA, Frank N, Soler D; et al. (2003). "Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R". Proc. Natl. Acad. Sci. U.S.A. 100 (20): 11589–93. doi:10.1073/pnas.2034927100. PMC 208802. PMID 13679572.
• Thompson MD, Storm van's Gravesande K, Galczenski H; et al. (2004). "A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha". Pharmacogenetics 13 (10): 641–9. doi:10.1097/01.fpc.0000054127.14659.42. PMID 14515063.
• Dunham A, Matthews LH, Burton J; et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Fukai H, Ogasawara Y, Migita O; et al. (2005). "Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma". Pharmacogenetics 14 (10): 683–90. doi:10.1097/00008571-200410000-00006. PMID 15454733.
• Pillai SG, Cousens DJ, Barnes AA; et al. (2005). "A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma". Pharmacogenetics 14 (9): 627–33. doi:10.1097/00008571-200409000-00007. PMID 15475736.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hui Y, Cheng Y, Smalera I; et al. (2005). "Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure". Circulation 110 (21): 3360–6. doi:10.1161/01.CIR.0000147775.50954.AA. PMID 15545522.
• Corrigan C, Mallett K, Ying S; et al. (2005). "Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis". J. Allergy Clin. Immunol. 115 (2): 316–22. doi:10.1016/j.jaci.2004.10.051. PMID 15696087.
• Uzonyi B, Lötzer K, Jahn S; et al. (2006). "Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6326–31. doi:10.1073/pnas.0601223103. PMC 1458877. PMID 16606835.
• Woszczek G, Chen LY, Nagineni S; et al. (2007). "IFN-gamma induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes". J. Immunol. 178 (8): 5262–70. doi:10.4049/jimmunol.178.8.5262. PMID 17404310.
• Klotsman M, York TP, Pillai SG; et al. (2007). "Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast". Pharmacogenet. Genomics 17 (3): 189–96. doi:10.1097/FPC.0b013e3280120043. PMID 17460547.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.