Fenoprofen

Fenoprofen
Systematic (IUPAC) name
2-(3-phenoxyphenyl)propanoic acid
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a681026
Pregnancy
category
  • US: D (Evidence of risk)
  • C
Routes of
administration
Oral
Legal status
Legal status
Pharmacokinetic data
Metabolism Major urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide.
Biological half-life 3 hours
Excretion Renal (~90%)
Identifiers
CAS Number 29679-58-1 YesY
ATC code M01AE04 (WHO)
PubChem CID 3342
IUPHAR/BPS 4820
DrugBank DB00573 YesY
ChemSpider 3225 YesY
UNII RA33EAC7KY YesY
KEGG D02350 YesY
ChEBI CHEBI:5004 YesY
ChEMBL CHEMBL1297 YesY
Chemical data
Formula C15H14O3
Molar mass 242.26986 g/mol
  (verify)

Fenoprofen is a non-steroidal anti-inflammatory drug. Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the USA as Nalfon.

As of 2015 the cost for a typical month of medication in the United States is 50 to 100 USD.[1]

Pharmacology

Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Contraindications

History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Drug interactions

Laboratory test interactions

False elevation in free and total serum T 3 as measured by Amerlex-M kit.

Brand names

References

  1. Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 8X. ISBN 9781284057560.

External links


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