Aceclofenac
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| Systematic (IUPAC) name | |
|---|---|
|
2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid | |
| Clinical data | |
| Trade names | Hifenac, Cincofen, Nacsiv, Acenac |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | oral, topical |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number |
89796-99-6  |
| ATC code | M01AB16 (WHO) M02AA25 (WHO) |
| PubChem | CID 71771 |
| ChemSpider |
64809  |
| UNII |
RPK779R03H |
| KEGG |
D01545 |
| ChEBI |
CHEBI:31159 |
| ChEMBL |
CHEMBL93645 |
| Chemical data | |
| Formula | C16H13Cl2NO4 |
| Molar mass | 353.02161 g/mol |
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| (what is this?) (verify) | |
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The dose is 100 mg twice daily.
It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children.
It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac. The incidence of gastric ulcerogenicity of aceclofenac has been reported to be significantly lower than that of the other frequently prescribed NSAIDs, for instance, 2-folds lesser than naproxen, 4-folds lesser than diclofenac, and 7-folds lesser than indomethacin. Aceclofenac is a crystalline powder with a molecular weight of 354.19. It is practically insoluble in water with good permeability. It is metabolized in human hepatocytes and human microsomes to form [2-(2',6'-dichloro-4'-hydroxy- phenylamino)phenyl] acetoxyacetic acid as the major metabolite, which is then further conjugated.[1]
Synthesis
References
- ↑ Karmoker, J.R.; Sarkar, S.; Joydhar, P.; Chowdhury, S.F. (2016). "Comparative in vitro equivalence evaluation of some Aceclofenac generic tablets marketed in Bangladesh" (PDF). The Pharma Innovation Journal 5: 03–07. Retrieved 2016-03-06.
- ↑ http://drugsynthesis.blogspot.co.uk/2012/03/synthesis-of-aceclofenac.html
- Sources
- British National Formulary 55, March 2008; ISBN 978-0-85369-776-3 p. 537
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