Fenbufen

Fenbufen

Systematic (IUPAC) name
4-(4-Biphenylyl)-4-oxobutanoic acid or 4-Oxo-4-(4-phenylphenyl)butanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
Legal status
Legal status	POM
Identifiers
CAS Number	36330-85-5
ATC code	M01AE05 (WHO)
PubChem	CID 3335
DrugBank	DB08981
ChemSpider	3218
UNII	9815R1WR9B
KEGG	D01344
ChEBI	CHEBI:31599
ChEMBL	CHEMBL277522
Chemical data
Formula	C16H14O3
Molar mass	254.2854
SMILES O=C(O)CCC(=O)c2ccc(c1ccccc1)cc2
InChI InChI=1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19) Key:ZPAKPRAICRBAOD-UHFFFAOYSA-N
(verify)

Fenbufen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives class.^[1]

It was introduced by American Cyanamid under the trade name Lederfen in the 1980s and was withdrawn from markets in the developed world due to liver toxicity in 2010.^{[2][3]:370, 383-384}

As of 2015 it was available in Taiwan and Thailand under several brand names.^[4]

See also

• Felbinac, another biphenyl based NSAID
• Florantyrone, having a different aryl group

References

1. Brogden RN. Non-steroidal anti-inflammatory analgesics other than salicylates. Drugs. 1986;32 Suppl 4:27-45. Review. PMID 3552584
2. Monthly Index of Medical Specialities Deleted products 2010
3. Lewis JH and Stine JG. Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists. Chapter 22 in Drug-Induced Liver Disease, 3rd Edition. Eds Neil Kaplowitz N and DeLeve LD. Academic Press, 2013 ISBN 9780123878182
4. Drugs.com Drugs.com international listings for fenbufen Page accessed June 25, 2015