Proquazone

Proquazone

Systematic (IUPAC) name
1-isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one
Identifiers
CAS Number	22760-18-5
ATC code	M01AX13 (WHO)
PubChem	CID 31508
ChemSpider	29222
UNII	42VPJ2980S
ChEMBL	CHEMBL268501
Chemical data
Formula	C18H18N2O
Molar mass	278.34832 g/mol
SMILES CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=CC=C3
InChI InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3 Key:JTIGKVIOEQASGT-UHFFFAOYSA-N
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Proquazone is a non-steroidal anti-inflammatory drug.^[1]

Synthesis

^{[2] [3]}

References

1. Clissold, S. P.; Beresford, R. (1987). "Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states". Drugs 33 (5): 478–502. doi:10.2165/00003495-198733050-00004. PMID 3297621.
2. Coombs, R. V.; Danna, R. P.; Denzer, M.; Hardtmann, G. E.; Huegi, B.; Koletar, G.; Koletar, J.; Ott, H.; Jukniewicz, E. (1973). "Synthesis and antiinflammatory activity of 1-alkyl-4-aryl-2(1H)-quinazolines and quinazolinethiones". Journal of Medicinal Chemistry 16 (11): 1237–1245. doi:10.1021/jm00269a006. ISSN 0022-2623.
3. G. Gamboni, W. Schmid and A. Sutter; GB1592687 (1981 to Sandoz).