FZD1

Frizzled class receptor 1
Identifiers
Symbols	FZD1 ; DKFZp564G072; FLJ95923
External IDs	OMIM: 603408 MGI: 1196625 HomoloGene: 20750 IUPHAR: 229 GeneCards: FZD1 Gene
Gene ontology Molecular function • G-protein coupled receptor activity • receptor binding • frizzled binding • protein binding • Wnt-protein binding • PDZ domain binding • Wnt-activated receptor activity Cellular component • plasma membrane • focal adhesion • cell surface • integral component of membrane • neuron projection Biological process • positive regulation of protein phosphorylation • membranous septum morphogenesis • muscular septum morphogenesis • outflow tract morphogenesis • G-protein coupled receptor signaling pathway • cell-cell signaling • neuron differentiation • negative regulation of BMP signaling pathway • epithelial cell differentiation • negative regulation of catenin import into nucleus • autocrine signaling • non-canonical Wnt signaling pathway • response to drug • canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation • canonical Wnt signaling pathway involved in osteoblast differentiation • regulation of osteoblast differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • lung alveolus development • positive regulation of sequence-specific DNA binding transcription factor activity • hard palate development • canonical Wnt signaling pathway • cellular response to vitamin D • cellular response to growth factor stimulus • cellular response to peptide hormone stimulus • negative regulation of canonical Wnt signaling pathway • planar cell polarity pathway involved in neural tube closure • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8321	14362
Ensembl	ENSG00000157240	ENSMUSG00000044674
UniProt	Q9UP38	O70421
RefSeq (mRNA)	NM_003505	NM_021457
RefSeq (protein)	NP_003496	NP_067432
Location (UCSC)	Chr 7: 91.26 – 91.27 Mb	Chr 5: 4.75 – 4.76 Mb
PubMed search

Frizzled-1 is a protein that in humans is encoded by the FZD1 gene.^[1][2]

Function

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.^[2]

See also

• Frizzled

References

1. Sagara N, Toda G, Hirai M, Terada M, Katoh M (Nov 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
2. "Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)".

Further reading

• Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Aug 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
• Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, Aaronson SA (Oct 1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084.
• DeCostanzo AJ, Huang XP, Wang HY, Malbon CC (May 2002). "The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor". Naunyn-Schmiedeberg's Archives of Pharmacology 365 (5): 341–8. doi:10.1007/s00210-002-0540-3. PMID 12012019.
• Hering H, Sheng M (Jun 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Letters 521 (1-3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
• Zilberberg A, Yaniv A, Gazit A (Apr 2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway". The Journal of Biological Chemistry 279 (17): 17535–42. doi:10.1074/jbc.M311292200. PMID 14739301.
• Wu J, Klein TJ, Mlodzik M (Jul 2004). "Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity". PLoS Biology 2 (7): E158. doi:10.1371/journal.pbio.0020158. PMC 449784. PMID 15252441.
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
• Yang L, Yamasaki K, Shirakata Y, Dai X, Tokumaru S, Yahata Y, Tohyama M, Hanakawa Y, Sayama K, Hashimoto K (May 2006). "Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes". Journal of Dermatological Science 42 (2): 111–9. doi:10.1016/j.jdermsci.2005.12.011. PMID 16442268.

External links

• "Frizzled Receptors: FZD₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.