Neuromedin U receptor 1

Neuromedin U receptor 1
Identifiers
Symbols	NMUR1 ; (FM-3); FM-3; FM3; GPC-R; GPR66; NMU1R
External IDs	OMIM: 604153 MGI: 1341898 HomoloGene: 68501 IUPHAR: 298 ChEMBL: 1075178 GeneCards: NMUR1 Gene
Gene ontology Molecular function • neuromedin U receptor activity • G-protein coupled receptor activity • neuropeptide receptor activity Cellular component • intracellular • plasma membrane • integral component of plasma membrane • integral component of membrane Biological process • calcium ion transport • chloride transport • smooth muscle contraction • G-protein coupled receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • activation of phospholipase C activity • neuropeptide signaling pathway • calcium-mediated signaling • inositol phosphate-mediated signaling • positive regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10316	14767
Ensembl	ENSG00000171596	ENSMUSG00000026237
UniProt	Q9HB89	O55040
RefSeq (mRNA)	NM_006056	NM_010341
RefSeq (protein)	NP_006047	NP_034471
Location (UCSC)	Chr 2: 231.52 – 231.53 Mb	Chr 1: 86.39 – 86.39 Mb
PubMed search

Neuromedin-U receptor 1 is a protein that in humans is encoded by the NMUR1 gene.^[1][2]

See also

• Neuromedin U receptor
• Limostatin

References

1. Tan CP, McKee KK, Liu Q, Palyha OC, Feighner SD, Hreniuk DL, Smith RG, Howard AD (Dec 1998). "Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors". Genomics 52 (2): 223–9. doi:10.1006/geno.1998.5441. PMID 9782091.
2. "Entrez Gene: NMUR1 neuromedin U receptor 1".

Further reading

• Fujii R, Hosoya M, Fukusumi S, et al. (2000). "Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3.". J. Biol. Chem. 275 (28): 21068–74. doi:10.1074/jbc.M001546200. PMID 10783389.
• Szekeres PG, Muir AI, Spinage LD, et al. (2000). "Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3.". J. Biol. Chem. 275 (27): 20247–50. doi:10.1074/jbc.C000244200. PMID 10811630.
• Raddatz R, Wilson AE, Artymyshyn R, et al. (2000). "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.". J. Biol. Chem. 275 (42): 32452–9. doi:10.1074/jbc.M004613200. PMID 10899166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mori K, Miyazato M, Ida T, et al. (2005). "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.". EMBO J. 24 (2): 325–35. doi:10.1038/sj.emboj.7600526. PMC 545815. PMID 15635449.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.

External links

• "Neuromedin U Receptors: NMU1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• NMUR1 human gene location in the UCSC Genome Browser.
• NMUR1 human gene details in the UCSC Genome Browser.