Neuropeptide Y receptor Y1

Neuropeptide Y receptor Y1
Rendering based on PDB 2F1U​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2F1U​, 2IIL​
Identifiers
Symbols	NPY1R ; NPY1-R; NPYR
External IDs	OMIM: 162641 MGI: 104963 HomoloGene: 700 IUPHAR: 305 ChEMBL: 4777 GeneCards: NPY1R Gene
Gene ontology Molecular function • peptide YY receptor activity • pancreatic polypeptide receptor activity • neuropeptide Y receptor activity • protein binding Cellular component • cytosol • plasma membrane • integral component of plasma membrane • synaptic vesicle • axon Biological process • outflow tract morphogenesis • glucose metabolic process • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • locomotory behavior • feeding behavior • regulation of blood pressure • sensory perception of pain • peristalsis • response to estradiol • regulation of multicellular organism growth • positive regulation of vasoconstriction • negative regulation of hormone secretion • negative regulation of cytosolic calcium ion concentration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4886	18166
Ensembl	ENSG00000164128	ENSMUSG00000036437
UniProt	P25929	Q04573
RefSeq (mRNA)	NM_000909	NM_010934
RefSeq (protein)	NP_000900	NP_035064
Location (UCSC)	Chr 4: 163.32 – 163.34 Mb	Chr 8: 66.7 – 66.71 Mb
PubMed search

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.^[1][2]

Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Peptide YY

Antagonists

Peptide

• BVD-10 (selective NPY₁ antagonist, CAS# 262418-00-8)
• GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Non-peptide

• BIBO-3304 (CAS# 191868-14-1)
• BIBP-3226 (CAS# 159013-54-4)
• PD-160,170 (CAS# 181468-88-2)

See also

• Neuropeptide Y receptor

References

1. Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (Mar 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry 268 (9): 6703–7. PMID 8095935.
2. "Entrez Gene: NPY1R neuropeptide Y receptor Y1".

Further reading

• Wan CP, Lau BH (Feb 1995). "Neuropeptide Y receptor subtypes". Life Sciences 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438.
• Parker E, Van Heek M, Stamford A (Apr 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
• Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y". Biopolymers 60 (6): 420–37. doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475.
• Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C (Jun 1992). "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type". The Journal of Biological Chemistry 267 (16): 10935–8. PMID 1317848.
• Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (Jul 1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America 89 (13): 5794–8. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422.
• Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Sep 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.
• Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mély Y, Takeda K, Bucher B, Galzi JL (Feb 2002). "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor". The Journal of Biological Chemistry 277 (8): 6645–55. doi:10.1074/jbc.M107224200. PMID 11741903.
• Sheriff S, F Qureshy A, T Chance W, Kasckow JW, Balasubramaniam A (Jan 2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]". Peptides 23 (1): 87–96. doi:10.1016/S0196-9781(01)00583-6. PMID 11814622.
• Cox HM, Tough IR (Mar 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
• Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524.
• Cantó Soler MV, Gallo JE, Dodds RA, Hökfelt T, Villar MJ, Suburo AM (Sep 2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina". Glia 39 (3): 320–4. doi:10.1002/glia.10107. PMID 12203398.
• Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR (Jul 2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". The Journal of Pharmacology and Experimental Therapeutics 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544.
• Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Körner M, Waser B, Reubi JC (Dec 2004). "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia". Clinical Cancer Research 10 (24): 8426–33. doi:10.1158/1078-0432.CCR-04-0821. PMID 15623622.

External links

• "Neuropeptide Y Receptors: Y₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.