Adiponectin receptor 1

Adiponectin receptor 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3WXV​
Identifiers
Symbols	ADIPOR1 ; ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A
External IDs	OMIM: 607945 MGI: 1919924 HomoloGene: 69199 IUPHAR: 649 GeneCards: ADIPOR1 Gene
Gene ontology Molecular function • receptor activity • protein kinase binding • identical protein binding • metal ion binding • protein heterodimerization activity • adiponectin binding • adipokinetic hormone receptor activity Cellular component • plasma membrane • membrane • integral component of membrane • intrinsic component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • hormone-mediated signaling pathway • regulation of glucose metabolic process • regulation of lipid metabolic process • fatty acid oxidation • negative regulation of cell growth • leptin-mediated signaling pathway • adiponectin-activated signaling pathway • glucose homeostasis • positive regulation of JAK-STAT cascade • positive regulation of insulin receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51094	72674
Ensembl	ENSG00000159346	ENSMUSG00000026457
UniProt	Q96A54	Q91VH1
RefSeq (mRNA)	NM_001290553	NM_001306069
RefSeq (protein)	NP_001277482	NP_001292998
Location (UCSC)	Chr 1: 202.94 – 202.96 Mb	Chr 1: 134.42 – 134.43 Mb
PubMed search

Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene.^[1]

Structure

Similar to G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7 transmembrane domains. However, AdipoR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.^[1]

Function

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.^[1][2]

Ligands

Agonists

Peptide

• Adiponectin
• ADP-355^[3]
• ADP-399^[3]

Non-peptide

• AdipoRon^[4]
• (–)-Arctigenin^[5]
• Arctiin^[5]
• Gramine^[5]
• Matairesinol^[5]

Antagonists

Peptide

• ADP-400^[3]

See also

• Adiponectin receptor
• Adiponectin receptor 2

References

1. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature 423 (6941): 762–9. doi:10.1038/nature01705. PMID 12802337.
2. "Entrez Gene: ADIPOR1 adiponectin receptor 1".
3. Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Front Chem 2: 93. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.
4. Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature 503 (7477): 493–9. doi:10.1038/nature12656. PMID 24172895.
5. Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLoS ONE 8 (5): e63354. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.

Further reading

• Crimmins NA, Martin LJ (2007). "Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance.". Obesity Reviews 8 (5): 419–23. doi:10.1111/j.1467-789X.2007.00348.x. PMID 17716299.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lai CH, Chou CY, Ch'ang LY; et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yamauchi T, Kamon J, Ito Y; et al. (2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.". Nature 423 (6941): 762–9. doi:10.1038/nature01705. PMID 12802337.
• Kharroubi I, Rasschaert J, Eizirik DL, Cnop M (2004). "Expression of adiponectin receptors in pancreatic beta cells.". Biochem. Biophys. Res. Commun. 312 (4): 1118–22. doi:10.1016/j.bbrc.2003.11.042. PMID 14651988.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Civitarese AE, Jenkinson CP, Richardson D; et al. (2005). "Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.". Diabetologia 47 (5): 816–20. doi:10.1007/s00125-004-1359-x. PMID 15105989.
• Wang H, Zhang H, Jia Y; et al. (2004). "Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance.". Diabetes 53 (8): 2132–6. doi:10.2337/diabetes.53.8.2132. PMID 15277397.
• Staiger H, Kaltenbach S, Staiger K; et al. (2004). "Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism.". Diabetes 53 (9): 2195–201. doi:10.2337/diabetes.53.9.2195. PMID 15331527.
• Berner HS, Lyngstadaas SP, Spahr A; et al. (2005). "Adiponectin and its receptors are expressed in bone-forming cells.". Bone 35 (4): 842–9. doi:10.1016/j.bone.2004.06.008. PMID 15454091.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Punyadeera C, Zorenc AH, Koopman R; et al. (2005). "The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle.". Eur. J. Endocrinol. 152 (3): 427–36. doi:10.1530/eje.1.01872. PMID 15757860.
• Hara K, Horikoshi M, Kitazato H; et al. (2005). "Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.". Diabetologia 48 (7): 1307–14. doi:10.1007/s00125-005-1806-3. PMID 15918014.
• Damcott CM, Ott SH, Pollin TI; et al. (2005). "Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.". Diabetes 54 (7): 2245–50. doi:10.2337/diabetes.54.7.2245. PMID 15983228.
• Neumeier M, Weigert J, Schäffler A; et al. (2006). "Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors.". Biochem. Biophys. Res. Commun. 334 (3): 924–9. doi:10.1016/j.bbrc.2005.06.187. PMID 16023994.
• Zhang J, Holt H, Wang C; et al. (2005). "Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men.". Diabetes Care 28 (8): 2058–60. doi:10.2337/diacare.28.8.2058. PMID 16043761.
• Tang YT, Hu T, Arterburn M; et al. (2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.". J. Mol. Evol. 61 (3): 372–80. doi:10.1007/s00239-004-0375-2. PMID 16044242.
• Jonsson JR, Moschen AR, Hickman IJ; et al. (2006). "Adiponectin and its receptors in patients with chronic hepatitis C.". J. Hepatol. 43 (6): 929–36. doi:10.1016/j.jhep.2005.05.030. PMID 16139921.