SB-408,124

SB-408,124

Systematic (IUPAC) name
1-(6,8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)phenyl]urea
Identifiers
CAS Number	288150-92-5
PubChem	CID 4331799
IUPHAR/BPS	1704
ChemSpider	3536200
Chemical data
Formula	C19H18F2N4O
Molar mass	356.368 g/mol
SMILES c3cc(N(C)C)ccc3NC(=O)Nc1cc(C)nc2c1cc(F)cc2F
InChI InChI=1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26) Key:JTARFZSNUAGHRB-UHFFFAOYSA-N
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SB-408,124 is a drug which is a non-peptide antagonist selective for the orexin receptor subtype OX₁, with around 70x selectivity for OX₁ over OX₂ receptors, and improved oral bioavailability compared to the older OX₁ antagonist SB-334,867. It is used in scientific research into the function of orexinergic neurons in the body.^[1][2]

References

1. Langmead, CJ; Jerman, JC; Brough, SJ; Scott, C; Porter, RA; Herdon, HJ (2004). "Characterisation of the binding of 3H-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor". British Journal of Pharmacology 141 (2): 340–6. doi:10.1038/sj.bjp.0705610. PMC 1574197. PMID 14691055.
2. Peng, HY; Chang, HM; Chang, SY; Tung, KC; Lee, SD; Chou, D; Lai, CY; Chiu, CH; et al. (2008). "Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit". American Journal of Physiology. Endocrinology and Metabolism 295 (1): E117–29. doi:10.1152/ajpendo.90243.2008. PMID 18477704.