Haloxazolam

Haloxazolam

Systematic (IUPAC) name
10-bromo-11b-(2-fluorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
Clinical data
Trade names	Somelin (JP)
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
Legal status
Legal status	CA: Schedule IV DE: Anlage III (Prescription only) US: Schedule IV
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal
Identifiers
CAS Number	59128-97-1
ATC code	none
PubChem	CID 3563
DrugBank	DB01476
ChemSpider	3442
UNII	verifiedrevid = 461766568 M448L2V8XP verifiedrevid = 461766568
KEGG	D01758
ChEMBL	CHEMBL2104461
Chemical data
Formula	C17H14BrFN2O2
Molar mass	377.208 g/mol
SMILES Fc1ccccc1C42OCCN2CC(=O)Nc3c4cc(Br)cc3
InChI InChI=1S/C17H14BrFN2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22) Key:XDKCGKQHVBOOHC-UHFFFAOYSA-N
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Haloxazolam (marketed in Japan under the brand name Somelin), is a drug which is a benzodiazepine derivative.^[1][2][3] It has similar hypnotic properties as the benzodiazepine drugs triazolam, temazepam, and flunitrazepam and as such is indicated for the treatment insomnia.^[4] A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons, whereas estazolam affects both alpha and gamma motor neurons.^[5]

See also

• Benzodiazepine

References

1. Tanaka, E; Terada, M; Misawa, S; Wakasugi, C (1996). "Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel". Journal of Chromatography B 682 (1): 173–8. doi:10.1016/0378-4347(96)00121-1. PMID 8832439.
2. "Benzodiazepine Names". non-benzodiazepines.org.uk. Retrieved 2009-04-05.
3. Guan, F; Seno, H; Ishii, A; Watanabe, K; Kumazawa, T; Hattori, H; Suzuki, O (1999). "Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine". Journal of analytical toxicology 23 (1): 54–61. doi:10.1093/jat/23.1.54. PMID 10022210.
4. Tan, X; Uchida, S; Matsuura, M; Nishihara, K; Kojima, T (2003). "Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra". Psychiatry and clinical neurosciences 57 (1): 97–104. doi:10.1046/j.1440-1819.2003.01085.x. PMID 12519461.
5. Sakai, Y (1983). "Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems.". Japanese journal of pharmacology 33 (5): 1017–25. doi:10.1254/jjp.33.1017. PMID 6139494.