Clonazolam
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| Systematic (IUPAC) name | |
|---|---|
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6-(2-chlorophenyl)-1-methyl-8-nitro-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine | |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | 33887-02-4 |
| PubChem | CID 12317881 |
| ChemSpider | 15468596 |
| Chemical data | |
| Formula | C17H12ClN5O2 |
| Molar mass | 353.07 g/mol |
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Clonazolam (also known as clonitrazolam) is a benzodiazepine that has been sold online as a designer drug.[1][2]
The synthesis of clonazolam was first reported in 1971 and the drug was described as the most active compound in the series tested.[3][4]
Clonazolam is reputed to be highly potent, and concerns have been raised that clonazolam and flubromazolam in particular may pose comparatively higher risks than other designer benzodiazepines, due to their ability to produce strong sedation and amnesia at oral doses of as little as 0.5 mg.[5]
Legality
Sweden's public health agency suggested classifying clonazolam as hazardous substance on June 1, 2015.[6]
See also
References
- ↑ Laura M. Huppertz, Philippe Bisel, Folker Westphal, Florian Franz, Volker Auwärter, Bjoern Moosmann (April 2015). "Characterization of the four designer benzodiazepines clonazolam, deschloroetizolam, flubromazolam, and meclonazepam, and identification of their in vitro metabolites". Forensic Toxicology 33: 388–395. doi:10.1007/s11419-015-0277-6.
- ↑ Markus R. Meyer, Madeleine Pettersson Bergstrand, Anders Helander, Olof Beck (2016). "Identification of main human urinary metabolites of the designer nitrobenzodiazepines clonazolam, meclonazepam, and nifoxipam by nano-liquid chromatography-high-resolution mass spectrometry for drug testing purposes". Analytical and Bioanalytical Chemistry. doi:10.1007/s00216-016-9439-6. PMID 27071765.
- ↑ Jackson B. Hester Jr., Allan D. Rudzik , Bharat V. Kamdar (November 1971). "6-Phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepines which have central nervous system depressant activity". Journal of Medicinal Chemistry 14 (11): 1078–1081. doi:10.1021/jm00293a015. PMID 5165540.
- ↑ René Borer, Max Dr. Gerecke, Emilio Dr. Kyburz (22 October 1986). "Patent EP 0072029 B1 - Triazolobenzazepines, process and intermediates for their preparation and medicines containing them". Retrieved 6 August 2015.
- ↑ Bjoern Moosmann, Leslie A King, Volker Auwärter (June 2015). "Designer benzodiazepines: A new challenge". World Psychiatry 14 (2): 248. doi:10.1002/wps.20236. PMC: 4471986. PMID 26043347.
- ↑ "23 nya ämnen kan klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. Retrieved 6 August 2015.
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