Flubromazolam
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| Systematic (IUPAC) name | |
|---|---|
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8-bromo-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a] [1,4]benzodiazepine | |
| Clinical data | |
| Legal status |
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| Identifiers | |
| CAS Number | 612526-40-6 |
| PubChem | CID 21930924 |
| ChemSpider | 10684757 |
| Chemical data | |
| Formula | C17H12BrFN4 |
| Molar mass | 371.21 g·mol−1 |
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Flubromazolam[1][2] is a benzodiazepine derivative closely related to triazolam and flubromazepam that has been sold online as a designer drug.[3][4] Flubromazolam is reputed to be highly potent, and concerns have been raised that clonazolam and flubromazolam in particular may pose comparatively higher risks than other designer benzodiazepines, due to their ability to produce strong sedation and amnesia at oral doses of as little as 0.5mg.[5] Life-threatening adverse reactions have been observed at doses of only 3mg of flubromazolam.[6]
Legal status
Flubromazolam has been classified as an illegal substance in Sweden after seizures by customs and police, as well as indications from the EMCDDA of wider use as a recreational drug.[7]
Flubromazolam is illegal in Switzerland as of December 2015.[8]
See also
References
- ↑ René Borer, Max Dr. Gerecke, Emilio Dr. Kyburz (22 October 1986). "Patent EP 0072029 B1 - Triazolobenzazepines, process and intermediates for their preparation and medicines containing them". Retrieved 6 August 2015.
- ↑ Jackson B. Hester Jr., Allan D. Rudzik , Bharat V. Kamdar (November 1971). "6-Phenyl-4H-s-triazolo[4,3-a] [1,4]benzodiazepines which have central nervous system depressant activity". Journal of Medicinal Chemistry 14 (11): 1078–1081. doi:10.1021/jm00293a015. PMID 5165540.
- ↑ "Flubromazolam". Cayman Chemical. Retrieved 20 November 2015.
- ↑ Laura M. Huppertz, Philippe Bisel, Folker Westphal, Florian Franz, Volker Auwärter, Bjoern Moosmann (April 2015). "Characterization of the four designer benzodiazepines clonazolam, deschloroetizolam, flubromazolam, and meclonazepam, and identification of their in vitro metabolites". Forensic Toxicology. doi:10.1007/s11419-015-0277-6.
- ↑ Bjoern Moosmann, Leslie A King, Volker Auwärter (June 2015). "Designer benzodiazepines: A new challenge". World Psychiatry 14 (2): 248. doi:10.1002/wps.20236. PMID 26043347.
- ↑ Magdalena Łukasik-Głębocka, Karina Sommerfeld, Artur Teżyk, Barbara Zielińska-Psuja, Paweł Panieński, Czesław Żaba (November 2015). "Flubromazolam – A new life-threatening designer benzodiazepine". Clinical Toxicology. doi:10.3109/15563650.2015.1112907. PMID 26585557.
- ↑ "Fler ämnen föreslås bli klassade som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten.
- ↑ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien". Der Bundesrat.
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