Sarmazenil

Sarmazenil

Systematic (IUPAC) name
Ethyl 7-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	78771-13-8
ATCvet code	QV03AB91(WHO)
PubChem	CID 71231
ChemSpider	64366
UNII	F84AE7X24P
ChEMBL	CHEMBL46547
Chemical data
Formula	C15H14ClN3O3
Molar mass	319.743 g/mol
SMILES CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC=C3Cl)C
InChI InChI=1S/C15H14ClN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3 Key:WSDBAFQWNWJTNG-UHFFFAOYSA-N
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Sarmazenil (Ro15-3505) is a drug from the benzodiazepine family. It acts as a partial inverse agonist of benzodiazepine receptors,^[1] meaning that it causes the opposite effects to most benzodiazepine drugs, and instead acts as an anxiogenic and convulsant. It is used in veterinary medicine to reverse the effects of benzodiazepine sedative drugs in order to rapidly re-awaken anesthetized animals.^[2][3][4]

See also

• Benzodiazepine
• Flumazenil

References

1. López-Romero B, Evrard G, Durant F, Sevrin M, George P (1998). "Molecular structure and stereoelectronic properties of sarmazenil--a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors): comparison with bretazenil and flumazenil". Bioorganic and Medicinal Chemistry 6 (10): 1745–57. doi:10.1016/S0968-0896(98)00117-5. PMID 9839004.
2. Henke J, Roberts U, Otto K, Lendl C, Matis U, Brill T, Erhardt W (1996). "Clinical investigations of an i.m. combination anesthesia with fentanyl / climazolam / xylazine and postoperative i.v. antagonism with naloxone / sarmazenil / yohimbine in guinea pigs". Tierärztliche Praxis (in German) 24 (1): 85–7. PMID 8720962.
3. Janovsky M, Tataruch F, Ambuehl M, Giacometti M (2000). "A Zoletil-Rompun mixture as an alternative to the use of opioids for immobilization of feral red deer". Journal of Wildlife Diseases 36 (4): 663–9. doi:10.7589/0090-3558-36.4.663. PMID 11085427.
4. Walzer C, Huber C (2002). "Partial antagonism of tiletamine-zolazepam anesthesia in cheetah". Journal of Wildlife Diseases 38 (2): 468–72. doi:10.7589/0090-3558-38.2.468. PMID 12038151.