Cinolazepam

Cinolazepam

Systematic (IUPAC) name
(RS)-3-[9-Chloro-6-(2-fluorophenyl)-4-hydroxy-3-oxo-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-2-yl]propanenitrile
Clinical data
Trade names	Gerodorm
AHFS/Drugs.com	International Drug Names
Pregnancy category	?
Routes of administration	Oral
Legal status
Legal status	US: Schedule IV
Pharmacokinetic data
Bioavailability	90–100%
Metabolism	Hepatic
Biological half-life	9 hours[1]
Excretion	Renal
Identifiers
CAS Number	75696-02-5
ATC code	N05CD13 (WHO)
PubChem	CID 3033621
DrugBank	DB01594
ChemSpider	2298251
UNII	68P0556B0U
KEGG	D07328
ChEBI	CHEBI:59514
ChEMBL	CHEMBL2104926
Chemical data
Formula	C18H13ClFN3O2
Molar mass	357.8
Chirality	Racemic mixture
SMILES FC1=CC=CC=C1C2=NC(C(N(CCC#N)C3=C2C=C(C=C3)Cl)=O)O
InChI InChI=1S/C18H13ClFN3O2/c19-11-6-7-15-13(10-11)16(12-4-1-2-5-14(12)20)22-17(24)18(25)23(15)9-3-8-21/h1-2,4-7,10,17,24H,3,9H2 Key:XAXMYHMKTCNRRZ-UHFFFAOYSA-N
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Cinolazepam^[2] (marketed under the brand name Gerodorm)^[3] is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Due to its strong sedative properties, it is primarily used as an hypnotic.

Cinolazepam is not approved for sale in the United States or Canada.

See also

• Benzodiazepine

References

1. Saletu, B.; G. Kindshofer; P. Anderer; J. Grunberger (1987). "Short-term sleep laboratory studies with cinolazepam in situational insomnia induced by traffic noise.". International Journal of Clinical Pharmacology Research 7 (5): 407–18. PMID 2889679.
2. US Patent 4388313 Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the preparation thereof
3. Lannacher Romania (1999). "Gerodorm". Produse Gerot inregistrate in Romania (in Romanian). Archived from the original on 11 October 2006. Retrieved 17 August 2006.

External links

• Inchem.org - Cinolazepam