Alphenal

Alphenal

Systematic (IUPAC) name
5-phenyl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
Clinical data
Routes of administration	Oral
Legal status
Legal status	CA: Schedule IV US: Rx-only, Schedule III
Identifiers
CAS Number	115-43-5
ATC code	none
PubChem	CID 8274
ChemSpider	7975
UNII	7T7L08Q9JI
Synonyms	5-Phenyl-5-allylbarbituric acid
Chemical data
Formula	C13H12N2O3
Molar mass	244.246 g/mol
SMILES O=C1NC(=O)NC(=O)C1(c2ccccc2)C\C=C
InChI InChI=1S/C13H12N2O3/c1-2-8-13(9-6-4-3-5-7-9)10(16)14-12(18)15-11(13)17/h2-7H,1,8H2,(H2,14,15,16,17,18) Key:WOIGZSBYKGQJGL-UHFFFAOYSA-N
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Alphenal (Alphenal, Efrodal, Prophenal, Sanudorm), also known as 5-allyl-5-phenylbarbituric acid, is a barbiturate derivative developed in the 1920s.^[1] It has primarily anticonvulsant properties, and was used occasionally for the treatment of epilepsy or convulsions, although not as commonly as better known barbiturates such as phenobarbital.^{[2][3] [4][5]}

LD₅₀: Mouse (Oral): 280 mg/kg

References

1. DE Patent 526854
2. Carissimi M, Nuovi Barbiturici Alogenati. Farmaco. Ediozione scientifica. 17(6):390-413. (1962).
3. Martin, J. R.; Godel, T.; Hunkeler, W.; Jenck, F.; Moreau, J.-L.; Sleight, A. J.; Widmer, U. (2000). "Psychopharmacological Agents". doi:10.1002/0471238961.1619250313011820.a01.
4. Hans Brandenberger; Robert A. A. Maes (1997). Analytical Toxicology: For Clinical, Forensic, and Pharmaceutical Chemists. Walter de Gruyter. p. 348. ISBN 978-3-11-010731-9. Retrieved 19 May 2012.
5. Pelayo Camps García; Santiago Vázquez Cruz; Carmen Escolano Mirón (28 January 2005). Fundamentos de síntesis de fármacos. Edicions Universitat Barcelona. p. 161. ISBN 978-84-475-2876-9. Retrieved 19 May 2012.