U-89843A
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| Systematic (IUPAC) name | |
|---|---|
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6,7-dimethyl-2,4-dipyrrolidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine | |
| Clinical data | |
| Legal status |
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| Identifiers | |
| CAS Number |
157013-32-6  |
| PubChem | CID 154689 |
| Chemical data | |
| Formula | C16H23N5 |
| Molar mass | 285.387 g/mol |
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| (verify) | |
U-89843A (PNU-89843) is a sedative drug which acts as an agonist at GABAA receptors, specifically acting as a positive allosteric modulator selective for the α1, α3 and α6 subtypes.[1] It has sedative effects in animals but without causing ataxia, and also acts as an antioxidant and may have neuroprotective effects.[2] It was developed by a team at Upjohn in the 1990s.[3]
References
- ↑ Im, HK; Im, WB; Pregenzer, JF; Carter, DB; Hamilton, BJ (1995). "U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors". The Journal of Pharmacology and Experimental Therapeutics 275 (3): 1390–5. PMID 8531107.
- ↑ Bundy, GL; Ayer, DE; Banitt, LS; Belonga, KL; Mizsak, SA; Palmer, JR; Tustin, JM; Chin, JE; et al. (1995). "Synthesis of novel 2,4-diaminopyrrolo-2,3-dpyrimidines with antioxidant, neuroprotective, and antiasthma activity". Journal of Medicinal Chemistry 38 (21): 4161–3. doi:10.1021/jm00021a004. PMID 7473542.
- ↑ US Patent 5502187 Pharmaceutically active bicyclic-heterocyclic amines
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