Proxibarbital

Proxibarbital

Systematic (IUPAC) name
(RS)-5-allyl-5-(2-hydroxypropyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Identifiers
CAS Number	2537-29-3
ATC code	N05CA22 (WHO)
PubChem	CID 17336
ChemSpider	16406
Synonyms	Proxibarbital, Centralgol, Ipronal, 5-Allyl-5-(β-hydroxypropyl)barbituric acid
Chemical data
Formula	C10H14N2O4
Molar mass	226.229 g/mol
SMILES O=C1NC(=O)NC(=O)C1(CC(O)C)C\C=C
InChI InChI=1S/C10H14N2O4/c1-3-4-10(5-6(2)13)7(14)11-9(16)12-8(10)15/h3,6,13H,1,4-5H2,2H3,(H2,11,12,14,15,16) Key:VNLMRPAWAMPLNZ-UHFFFAOYSA-N
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Proxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956. It has anti-anxiety properties and in contrast to most barbiturates almost without hypnotic action.^[1]

It was also used in the treatment of migraine headaches in a similar manner to butalbital.^[2]

References

1. Zajdel, P.; Kulig, K.; Zejc, A. (2008). Zejc, A.; Gorczyca, M., eds. Chemia leków, podręcznik dla studentów farmacji i farmaceutów (in Polish). Warszawa, Poland. ISBN 978-83-200-3652-7.
2. Sulman, F. G.; Pfeifer, Y.; Tal, E. (1976). "Migraine therapy by enzyme induction with proxibarbital". Therapie der Gegenwart (in German) 115 (12): 2088–2103. PMID 14412.