Thiamylal

Thiamylal

Systematic (IUPAC) name
5-Allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status
Legal status	CA: Schedule IV US: Schedule III
Pharmacokinetic data
Metabolism	Hepatic
Biological half-life	14.3 h (cats)
Identifiers
CAS Number	77-27-0
ATCvet code	QN01AF90(WHO)
PubChem	CID 3032285
IUPHAR/BPS	7305
DrugBank	DB01154
ChemSpider	2297298
UNII	01T23W89FR
KEGG	D06106
ChEBI	CHEBI:9536
ChEMBL	CHEMBL440
Synonyms	Thiamylal, Thioseconal, Surital
Chemical data
Formula	C12H18N2O2S
Molar mass	254.35 g/mol
SMILES O=C1NC(=S)NC(=O)C1(C(C)CCC)C\C=C
InChI InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17) Key:XLOMZPUITCYLMJ-UHFFFAOYSA-N
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Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant, and hypnotic effects, and is used as a strong but short acting sedative. Thiamylal is still in current use, primarily for induction in surgical anaesthesia ^[1] or as an anticonvulsant to counteract side effects from other anaesthetics.^[2] It is the thiobarbiturate analogue of secobarbital.

References

1. Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatrica Taiwan. 2005 Sep-Oct;46(5):294-300.
2. Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV. Seizure after local anesthesia for nasopharyngeal angiofibroma. Kaohsiung Journal of Medical Sciences. 2007 Feb;23(2):97-100.