Devazepide
 | |
| Systematic (IUPAC) name | |
|---|---|
|
N-(1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl)-1H-indole-2-carboxamide | |
| Identifiers | |
| CAS Number |
103420-77-5  |
| ATC code | none |
| PubChem | CID 443375 |
| IUPHAR/BPS | 878 |
| ChemSpider |
391607  |
| UNII |
JE6P7QY7NH |
| KEGG |
D02693 |
| ChEMBL |
CHEMBL9506 |
| Chemical data | |
| Formula | C25H20N4O2 |
| Molar mass | 408.452 g/mol |
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| (what is this?) (verify) | |
Devazepide[1] (L-364,718, MK-329) is benzodiazepine drug, but with quite different actions from most benzodiazepines, lacking affinity for GABAA receptors and instead acting as an CCKA receptor antagonist.[2] It increases appetite and accelerates gastric emptying,[3][4] and has been suggested as a potential treatment for a variety of gastrointestinal problems including dyspepsia, gastroparesis and gastric reflux.[5] It is also widely used in scientific research into the CCKA receptor.[6][7]
Synthesis
Devazepide is synthesised in a similar manner to other benzodiazepines.[8][9]
See also
References
- ↑ US Patent 4820834
- ↑ Hill DR, Woodruff GN. Differentiation of central cholecystokinin receptor binding sites using the non-peptide antagonists MK-329 and L-365,260. Brain Research. 1990 Sep 3;526(2):276-83. PMID 2257485
- ↑ Cooper SJ, Dourish CT. Multiple cholecystokinin (CCK) receptors and CCK-monoamine interactions are instrumental in the control of feeding. Physiology and Behaviour. 1990 Dec;48(6):849-57. PMID 1982361
- ↑ Cooper SJ, Dourish CT, Clifton PG. CCK antagonists and CCK-monoamine interactions in the control of satiety. American Journal of Clinical Nutrition. 1992 Jan;55(1 Suppl):291S-295S. PMID 1728842
- ↑ Scarpignato C, Varga G, Corradi C. Effect of CCK and its antagonists on gastric emptying. Journal of Physiology Paris. 1993;87(5):291-300. PMID 8298606
- ↑ Weller A. The ontogeny of postingestive inhibitory stimuli: examining the role of CCK. Developmental Psychobiology. 2006 Jul;48(5):368-79. PMID 16770766
- ↑ Savastano DM, Covasa M. Intestinal nutrients elicit satiation through concomitant activation of CCK(1) and 5-HT(3) receptors. Physiology and Behaviour. 2007 Oct 22;92(3):434-42. PMID 17531277
- ↑ doi:10.1021/jm00120a002
- ↑ EP 1492540
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