Elsilimomab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Mouse |
| Target | IL-6 |
| Identifiers | |
| CAS Number |
468715-71-1  |
| ATC code | None |
| ChemSpider | none |
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Elsilimomab (also known as B-E8) is a mouse monoclonal antibody[1] and an immunosuppressive drug.
It (OPR-003) targets (and blocks) Interleukin-6.[2]
It has undergone a number of early stage clinical trails, e.g. for lymphoma and myeloma.[3]
It was used as a template to develop a high-affinity, antagonist, fully human anti-IL-6 mAb 1339.[3]
References
- ↑ "WHO Drug Information" (PDF).
p11:immunoglobulin G1, anti-(human interleukin 6) (mouse monoclonal B-E8 heavy chain), disulfide with mouse monoclonal B-E8 k-chain, dimer
- ↑ "First Fully Human Anti-IL6 Antibody Under Development". Oct 2006.
- 1 2 Fulciniti; Hideshima, T; Vermot-Desroches, C; Pozzi, S; Nanjappa, P; Shen, Z; Patel, N; Smith, ES; et al. (2009). "A high-affinity fully human anti-IL-6 mAb (OP-R003-1, 1339) for the treatment of Multiple Myeloma". Clinical cancer research : an official journal of the American Association for Cancer Research 15 (23): 7144–52. doi:10.1158/1078-0432.CCR-09-1483. PMC 2787636. PMID 19934301.
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