CD80

CD80 molecule

Rendering of 1DR9

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1DR9, 1I8L

Identifiers

Symbols

CD80 ; B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7

External IDs

OMIM: 112203 MGI: 101775 HomoloGene: 3804 GeneCards: CD80 Gene

Gene ontology
Molecular function	• protein binding • coreceptor activity
Cellular component	• intracellular • plasma membrane • external side of plasma membrane • cell surface • integral component of membrane
Biological process	• epidermal growth factor receptor signaling pathway • cell-cell signaling • fibroblast growth factor receptor signaling pathway • positive regulation of signal transduction • viral process • T cell costimulation • intracellular signal transduction • Fc-epsilon receptor signaling pathway • T cell activation • positive regulation of interleukin-2 biosynthetic process • innate immune response • positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process • positive regulation of T-helper 1 cell differentiation • positive regulation of transcription, DNA-templated • positive regulation of alpha-beta T cell proliferation • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of peptidyl-tyrosine phosphorylation • cellular response to lipopolysaccharide
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

941

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
119.52 – 119.56 Mb

Chr 16:
38.46 – 38.49 Mb

PubMed search

Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4^[1]^[2] (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells.

References

↑ Peach, R J; Bajorath J; Naemura J; Leytze G; Greene J; Aruffo A; Linsley P S (Sep 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". J. Biol. Chem. (UNITED STATES) 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. ISSN 0021-9258. PMID 7545666.
↑ Stamper, C C; Zhang Y; Tobin J F; Erbe D V; Ikemizu S; Davis S J; Stahl M L; Seehra J; Somers W S; Mosyak L (Mar 2001). "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses". Nature (England) 410 (6828): 608–11. doi:10.1038/35069118. ISSN 0028-0836. PMID 11279502.

Knolle PA, Gerken G (2000). "Local control of the immune response in the liver.". Immunol. Rev. 174: 21–34. doi:10.1034/j.1600-0528.2002.017408.x. PMID 10807504.
Henz BM, Maurer M, Lippert U; et al. (2001). "Mast cells as initiators of immunity and host defense.". Exp. Dermatol. 10 (1): 1–10. doi:10.1034/j.1600-0625.2001.100101.x. PMID 11168574.
Chang TT, Kuchroo VK, Sharpe AH (2002). "Role of the B7-CD28/CTLA-4 pathway in autoimmune disease". Curr. Dir. Autoimmun. Current Directions in Autoimmunity 5: 113–30. doi:10.1159/000060550. ISBN 3-8055-7308-1. PMID 11826754.
Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.
Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB J. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.
Freeman GJ, Disteche CM, Gribben JG; et al. (1992). "The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21". Blood 79 (2): 489–94. PMID 1370389.
Selvakumar A, Mohanraj BK, Eddy RL; et al. (1992). "Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7". Immunogenetics 36 (3): 175–81. doi:10.1007/BF00661094. PMID 1377173.
Freeman GJ, Gray GS, Gimmi CD; et al. (1991). "Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7". J. Exp. Med. 174 (3): 625–31. doi:10.1084/jem.174.3.625. PMC 2118924. PMID 1714935.
Freeman GJ, Freedman AS, Segil JM; et al. (1989). "B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells". J. Immunol. 143 (8): 2714–22. PMID 2794510.
Weiskirchen R, Pino JD, Macalma T; et al. (1996). "The cysteine-rich protein family of highly related LIM domain proteins". J. Biol. Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.
Lanier LL, O'Fallon S, Somoza C; et al. (1995). "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL". J. Immunol. 154 (1): 97–105. PMID 7527824.
Chirmule N, McCloskey TW, Hu R; et al. (1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". J. Immunol. 155 (2): 917–24. PMID 7541827.
Peach RJ, Bajorath J, Naemura J; et al. (1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". J. Biol. Chem. 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. PMID 7545666.
Tuosto L, Piazza C, Moretti S; et al. (1995). "Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis". Eur. J. Immunol. 25 (10): 2917–22. doi:10.1002/eji.1830251031. PMID 7589092.
Chirmule N, Oyaizu N, Saxinger C, Pahwa S (1994). "Nef protein of HIV-1 has B-cell stimulatory activity". AIDS 8 (6): 733–4. doi:10.1097/00002030-199406000-00002. PMID 8086129.
Weiskirchen R, Bister K (1993). "Suppression in transformed avian fibroblasts of a gene (crp) encoding a cysteine-rich protein containing LIM domains". Oncogene 8 (9): 2317–24. PMID 8361751.
Dono M, Zupo S, Augliera A; et al. (1996). "Subepithelial B cells in the human palatine tonsil. II. Functional characterization". Eur. J. Immunol. 26 (9): 2043–9. doi:10.1002/eji.1830260912. PMID 8814244.
Reeves RH, Patch D, Sharpe AH; et al. (1997). "The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3". Mamm. Genome 8 (8): 581–2. doi:10.1007/s003359900508. PMID 9250865.
Olivares EG, Montes MJ, Oliver C; et al. (1997). "Cultured human decidual stromal cells express B7-1 (CD80) and B7-2 (CD86) and stimulate allogeneic T cells". Biol. Reprod. 57 (3): 609–15. doi:10.1095/biolreprod57.3.609. PMID 9282998.
Weiskirchen R, Erdel M, Utermann G, Bister K (1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.

PDB gallery

1dr9: CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)

1i8l: HUMAN B7-1/CTLA-4 CO-STIMULATORY COMPLEX

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Proteins: B7 family (see also immunoglobulin superfamily)

B7 ligands	B7-1 B7-2 B7-DC B7-H1 B7-H2 B7-H3 B7-H4

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CD80

See also

References

Further reading