CD37

CD37 molecule
Identifiers
Symbols	CD37 ; GP52-40; TSPAN26
External IDs	OMIM: 151523 MGI: 88330 HomoloGene: 20422 GeneCards: CD37 Gene
Gene ontology Molecular function • protein binding Cellular component • immunological synapse • membrane • integral component of membrane • extracellular exosome Biological process • positive regulation of immunoglobulin production • regulation of humoral immune response • negative regulation of cell proliferation • negative regulation of myeloid dendritic cell activation • defense response to protozoan • regulation of defense response to virus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	951	12493
Ensembl	ENSG00000104894	ENSMUSG00000030798
UniProt	P11049	Q61470
RefSeq (mRNA)	NM_001040031	NM_001290802
RefSeq (protein)	NP_001035120	NP_001277731
Location (UCSC)	Chr 19: 49.34 – 49.34 Mb	Chr 7: 45.23 – 45.24 Mb
PubMed search

Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.^[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.^[2]

See also

• Cluster of differentiation

References

1. Virtaneva KI, Angelisova P, Baumruker T, Horejsi V, Nevanlinna H, Schroder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics 37 (6): 461–465. doi:10.1007/BF00222471. PMID 8436422.
2. "Entrez Gene: CD37 CD37 molecule".

Further reading

• Horejsí V, Vlcek C (1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63". FEBS Lett. 288 (1–2): 1–4. doi:10.1016/0014-5793(91)80988-F. PMID 1879540.
• Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
• Classon BJ, Williams AF, Willis AC, et al. (1990). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". J. Exp. Med. 172 (3): 1007–1007. doi:10.1084/jem.172.3.1007. PMC 2188538. PMID 2388030.
• Classon BJ, Williams AF, Willis AC, et al. (1989). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". J. Exp. Med. 169 (4): 1497–1502. doi:10.1084/jem.169.4.1497. PMC 2189247. PMID 2466944.
• Schwartz-Albiez R, Dörken B, Hofmann W, Moldenhauer G (1988). "The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein". J. Immunol. 140 (3): 905–14. PMID 3257508.
• Angelisová P, Hilgert I, Horejsí V (1994). "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins". Immunogenetics 39 (4): 249–56. doi:10.1007/BF00188787. PMID 8119731.
• Wright MD, Rochelle JM, Tomlinson MG, et al. (1993). "Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication". Int. Immunol. 5 (2): 209–216. doi:10.1093/intimm/5.2.209. PMID 8452817.
• Serru V, Le Naour F, Billard M, et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
• Okochi H, Mine T, Nashiro K, et al. (1999). "Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract". J. Clin. Gastroenterol. 29 (1): 63–67. doi:10.1097/00004836-199907000-00016. PMID 10405235.
• Matsumoto K, Bochner BS, Wakiguchi H, Kurashige T (1999). "Functional expression of transmembrane 4 superfamily molecules on human eosinophils". Int. Arch. Allergy Immunol. 120 Suppl 1: 38–44. doi:10.1159/000053592. PMID 10529602.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• van Spriel AB, Puls KL, Sofi M, et al. (2004). "A regulatory role for CD37 in T cell proliferation". J. Immunol. 172 (5): 2953–61. doi:10.4049/jimmunol.172.5.2953. PMID 14978098.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Meyer-Wentrup F, Figdor CG, Ansems M, et al. (2007). "Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production". J. Immunol. 178 (1): 154–62. doi:10.4049/jimmunol.178.1.154. PMID 17182550.
• Zhao X, Lapalombella R, Joshi T, et al. (2007). "Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical". Blood 110 (7): 2569–2577. doi:10.1182/blood-2006-12-062927. PMC 1988922. PMID 17440052.

External links

• CD37 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.