LILRB2

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
PDB rendering based on 2dyp.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DYP​, 2GW5​, 4LLA​
Identifiers
Symbols	LILRB2 ; CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10; MIR10
External IDs	OMIM: 604815 HomoloGene: 136797 GeneCards: LILRB2 Gene
Gene ontology Molecular function • receptor activity • protein binding • protein phosphatase 1 binding • MHC class Ib protein binding • inhibitory MHC class I receptor activity • MHC class I protein binding • cell adhesion molecule binding Cellular component • extracellular space • cytoplasm • plasma membrane • integral component of plasma membrane • cell surface • membrane Biological process • adaptive immune response • negative regulation of antigen processing and presentation • positive regulation of tolerance induction • positive regulation of T cell tolerance induction • immune response-inhibiting cell surface receptor signaling pathway • Fc receptor mediated inhibitory signaling pathway • immune response • cellular defense response • signal transduction • cell surface receptor signaling pathway • cell-cell signaling • positive regulation of interleukin-6 production • heterotypic cell-cell adhesion • positive regulation of T cell proliferation • negative regulation of T cell proliferation • positive regulation of regulatory T cell differentiation • regulation of immune response • negative regulation of immune response • negative regulation of calcium ion transport • cellular response to lipopolysaccharide • regulation of dendritic cell differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10288	n/a
Ensembl	ENSG00000131042	n/a
UniProt	Q8N423	n/a
RefSeq (mRNA)	NM_001080978	n/a
RefSeq (protein)	NP_001074447	n/a
Location (UCSC)	Chr 19: 54.22 – 54.22 Mb	n/a
PubMed search		n/a

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.^[1][2][3]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

LILRB2 has been shown to interact with PTPN6.^[4][5]

See also

• Cluster of differentiation

References

1. Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (Jun 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". J Exp Med 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.
2. Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806.
3. "Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2".
4. Fanger, N A; Cosman D; Peterson L; Braddy S C; Maliszewski C R; Borges L (Nov 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". Eur. J. Immunol. (GERMANY) 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. ISSN 0014-2980. PMID 9842885.
5. Colonna, M; Samaridis J; Cella M; Angman L; Allen R L; O'Callaghan C A; Dunbar R; Ogg G S; Cerundolo V; Rolink A (Apr 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". J. Immunol. (UNITED STATES) 160 (7): 3096–100. ISSN 0022-1767. PMID 9531263.

Further reading

• Suciu-Foca N, Cortesini R (2007). "Central role of ILT3 in the T suppressor cell cascade.". Cell. Immunol. 248 (1): 59–67. doi:10.1016/j.cellimm.2007.01.013. PMID 17923119.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Wagtmann N, Rojo S, Eichler E, et al. (1997). "A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors". Curr. Biol. 7 (8): 615–8. doi:10.1016/S0960-9822(06)00263-6. PMID 9259559.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Colonna M, Navarro F, Bellón T, et al. (1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". J. Exp. Med. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.
• Colonna M, Samaridis J, Cella M, et al. (1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". J. Immunol. 160 (7): 3096–100. PMID 9531263.
• Borges L, Hsu ML, Fanger N, et al. (1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J. Immunol. 159 (11): 5192–6. PMID 9548455.
• Fanger NA, Cosman D, Peterson L, et al. (1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". Eur. J. Immunol. 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.
• Allan DS, Colonna M, Lanier LL, et al. (1999). "Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells". J. Exp. Med. 189 (7): 1149–56. doi:10.1084/jem.189.7.1149. PMC 2193000. PMID 10190906.
• Lepin EJ, Bastin JM, Allan DS, et al. (2001). "Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors". Eur. J. Immunol. 30 (12): 3552–61. doi:10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L. PMID 11169396.
• Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530.
• Chang CC, Ciubotariu R, Manavalan JS, et al. (2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nat. Immunol. 3 (3): 237–43. doi:10.1038/ni760. PMID 11875462.
• Willcox BE, Thomas LM, Chapman TL, et al. (2003). "Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18". BMC Struct. Biol. 2: 6. doi:10.1186/1472-6807-2-6. PMC 130215. PMID 12390682.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shiroishi M, Tsumoto K, Amano K, et al. (2003). "Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 8856–61. doi:10.1073/pnas.1431057100. PMC 166403. PMID 12853576.
• Nakajima H, Asai A, Okada A, et al. (2004). "Transcriptional regulation of ILT family receptors". J. Immunol. 171 (12): 6611–20. doi:10.4049/jimmunol.171.12.6611. PMID 14662864.
• Papanikolaou NA, Vasilescu ER, Suciu-Foca N (2005). "Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4". Hum. Immunol. 65 (7): 700–5. doi:10.1016/j.humimm.2004.04.003. PMID 15301858.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• LILRB2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• LILRB2 human gene location in the UCSC Genome Browser.
• LILRB2 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.