ITGA5

Integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3VI3​, 3VI4​, 4WJK​, 4WK0​, 4WK2​, 4WK4​
Identifiers
Symbols	ITGA5 ; CD49e; FNRA; VLA-5; VLA5A
External IDs	OMIM: 135620 MGI: 96604 HomoloGene: 20508 ChEMBL: 3955 GeneCards: ITGA5 Gene
Gene ontology Molecular function • platelet-derived growth factor receptor binding • integrin binding • protein binding • vascular endothelial growth factor receptor 2 binding • metal ion binding Cellular component • ruffle • endoplasmic reticulum • Golgi apparatus • plasma membrane • cell-cell junction • focal adhesion • integrin complex • external side of plasma membrane • cell surface • cytoplasmic vesicle • ruffle membrane • synapse • alphav-beta3 integrin-vitronectin complex Biological process • angiogenesis • cell-substrate junction assembly • cell adhesion • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • leukocyte cell-cell adhesion • integrin-mediated signaling pathway • axon guidance • blood coagulation • memory • viral process • extracellular matrix organization • positive regulation of vascular endothelial growth factor receptor signaling pathway • cell-substrate adhesion • cell-cell adhesion mediated by integrin • heterotypic cell-cell adhesion • wound healing, spreading of epidermal cells • endodermal cell differentiation • positive regulation of peptidyl-tyrosine phosphorylation • leukocyte migration • negative regulation of anoikis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3678	16402
Ensembl	ENSG00000161638	ENSMUSG00000000555
UniProt	P08648	P11688
RefSeq (mRNA)	NM_002205	NM_010577
RefSeq (protein)	NP_002196	NP_034707
Location (UCSC)	Chr 12: 54.4 – 54.42 Mb	Chr 15: 103.34 – 103.37 Mb
PubMed search

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.^[1]

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.^[2]

Interactions

ITGA5 has been shown to interact with GIPC1.^[3]

See also

• Cluster of differentiation
• Integrin

References

1. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS; et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.
2. "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)".
3. Tani, T T; Mercurio A M (Sep 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. (United States) 276 (39): 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315.

Further reading

• Ruoslahti E (1996). "Integrin signaling and matrix assembly.". Tumour Biol. 17 (2): 117–24. doi:10.1159/000217975. PMID 8658014.
• Coulombel L, Auffray I, Gaugler MH, Rosemblatt M (1997). "Expression and function of integrins on hematopoietic progenitor cells.". Acta Haematol. 97 (1–2): 13–21. doi:10.1159/000203655. PMID 8980606.
• Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.
• Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216.

External links

• CD49e Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• ITGA5 Info with links in the Cell Migration Gateway