Langerin

CD207 molecule, langerin
Rendering based on PDB 3C22​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3C22​, 3KQG​, 3P5D​, 3P5E​, 3P5F​, 3P5G​, 3P5H​, 3P5I​, 3P7F​, 3P7G​, 3P7H​, 4AK8​, 4N32​, 4N33​, 4N34​, 4N35​, 4N36​, 4N37​, 4N38​
Identifiers
Symbols	CD207 ; CLEC4K
External IDs	OMIM: 604862 MGI: 2180021 HomoloGene: 9252 GeneCards: CD207 Gene
Gene ontology Molecular function • mannose binding • carbohydrate binding Cellular component • plasma membrane • integral component of membrane • endocytic vesicle • clathrin-coated endocytic vesicle membrane • early endosome membrane Biological process • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • antigen processing and presentation of exogenous peptide antigen via MHC class I • defense response to virus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50489	246278
Ensembl	ENSG00000116031	ENSMUSG00000034783
UniProt	Q9UJ71	Q8VBX4
RefSeq (mRNA)	NM_015717	NM_144943
RefSeq (protein)	NP_056532	NP_659192
Location (UCSC)	Chr 2: 70.83 – 70.84 Mb	Chr 6: 83.67 – 83.68 Mb
PubMed search

CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene.^[1][2] Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.^[2][3]

Function

The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally it is known by the name C-type lectin domain family 4 member K (CD antigen CD207). It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.^[1]

Clinical significance

Langerin on mucosal Langerhans cells of the human genital epithelium binds to HIV-1 and subsequently internalizes it into Birbeck granules to be degraded.^[4][5]

See also

• Paul Langerhans
• Langerhans cell

References

1. EntrezGene 50489
2. Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y, Duvert-Frances Vé, Vincent C, Schmitt D (2000). "Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, is an Endocytic Receptor that Induces the Formation of Birbeck Granules". Immunity 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407.
3. Valladeau J, Clair-Moninot Vé, Dezutter-Dambuyant C, Pin J-J, Kissenpfennig A, Mattéi M-G, Ait-Yahia S, Bates EEM, Malissen B (2002). "Identification of Mouse Langerin/CD207 in Langerhans Cells and Some Dendritic Cells of Lymphoid Tissues". Journal of Immunology 168 (2): 782–92. doi:10.4049/jimmunol.168.2.782. PMID 11777972.
4. De Witte L, Nabatov A, Pion M, Fluitsma D, De Jong MAWP, De Gruijl T, Piguet V, Van Kooyk Y, Geijtenbeek TBH (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nature Medicine 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373.
5. Turville S, Wilkinson J, Cameron P, Dable J, Cunningham AL (2003). "The role of dendritic cell C-type lectin receptors in HIV pathogenesis". Journal of Leukocyte Biology 74 (5): 710–8. doi:10.1189/jlb.0503208. PMID 12960229.

Further reading

• Valladeau J, Dezutter-Dambuyant C, Saeland S (2003). "Langerin/CD207 Sheds Light on Formation of Birbeck Granules and Their Possible Function in Langerhans Cells". Immunologic Research 28 (2): 93–107. doi:10.1385/IR:28:2:93. PMID 14610287.
• Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". The FASEB Journal 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.
• The Sanger Centre, The Washington University Genome Sequencing Center (1998). "Toward a Complete Human Genome Sequence". Genome Research 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y, Duvert-Frances Vé, Vincent C, Schmitt D (2000). "Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, is an Endocytic Receptor that Induces the Formation of Birbeck Granules". Immunity 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407.
• Turville SG, Cameron PU, Handley A, Lin G, Pöhlmann S, Doms RW, Cunningham AL (2002). "Diversity of receptors binding HIV on dendritic cell subsets". Nature Immunology 3 (10): 975–83. doi:10.1038/ni841. PMID 12352970.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A (2004). "Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells". Journal of Clinical Investigation 113 (5): 701–8. doi:10.1172/JCI200419655. PMC 351318. PMID 14991068.
• Vashishta A, Fusek M, Větvička V (2005). "Possible role of procathepsin D in human cancer". Folia Microbiologica 50 (1): 71–6. doi:10.1007/BF02931296. PMID 15954536.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Research 14 (10b): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Verdijk P, Dijkman R, Plasmeijer EI, Mulder AA, Zoutman WH, Mieke Mommaas A, Tensen CP (2005). "A Lack of Birbeck Granules in Langerhans Cells is Associated with a Naturally Occurring Point Mutation in the Human Langerin Gene". Journal of Investigative Dermatology 124 (4): 714–7. doi:10.1111/j.0022-202X.2005.23645.x. PMID 15816828.
• Bousarghin L (2005). "Human papillomavirus 16 virus-like particles use heparan sulfates to bind dendritic cells and colocalize with langerin in Langerhans cells". Journal of General Virology 86 (5): 1297. doi:10.1099/vir.0.80559-0.
• He B, Qiao X, Klasse PJ, Chiu A, Chadburn A, Knowles DM, Moore JP, Cerutti A (2006). "HIV-1 Envelope Triggers Polyclonal Ig Class Switch Recombination through a CD40-Independent Mechanism Involving BAFF and C-Type Lectin Receptors". Journal of Immunology 176 (7): 3931–41. doi:10.4049/jimmunol.176.7.3931. PMID 16547227.
• Ward EM, Stambach NS, Drickamer K, Taylor ME (2006). "Polymorphisms in Human Langerin Affect Stability and Sugar Binding Activity". Journal of Biological Chemistry 281 (22): 15450–6. doi:10.1074/jbc.M511502200. PMID 16567809.
• de Witte L, Nabatov A, Pion M, Fluitsma D, De Jong MAWP, De Gruijl T, Piguet V, Van Kooyk Y, Geijtenbeek TBH (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nature Medicine 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373.
• Kaplan DH, Li MO, Jenison MC, Shlomchik WD, Flavell RA, Shlomchik MJ (2007). "Autocrine/paracrine TGF 1 is required for the development of epidermal Langerhans cells". Journal of Experimental Medicine 204 (11): 2545–52. doi:10.1084/jem.20071401. PMC 2118472. PMID 17938236.

External links

• CD207 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)