SIGLEC5

Sialic acid binding Ig-like lectin 5
Rendering based on PDB 2ZG1​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2ZG1​, 2ZG2​, 2ZG3​
Identifiers
Symbols	SIGLEC5 ; CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5
External IDs	OMIM: 604200 HomoloGene: 55783 GeneCards: SIGLEC5 Gene
Gene ontology Molecular function • protein binding • carbohydrate binding Cellular component • integral component of membrane Biological process • cell adhesion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8778	n/a
Ensembl	ENSG00000105501	n/a
UniProt	O15389	n/a
RefSeq (mRNA)	NM_003830	n/a
RefSeq (protein)	NP_003821	n/a
Location (UCSC)	Chr 19: 51.61 – 51.65 Mb	n/a
PubMed search		n/a

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene.^[1][2] SIGLEC5 has also been designated CD170 (cluster of differentiation 170).

References

1. Kim HS (Jun 1999). "Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping". Cytogenet Cell Genet 84 (1–2): 96. doi:10.1159/000015227. PMID 10343116.
2. "Entrez Gene: SIGLEC5 sialic acid binding Ig-like lectin 5".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Cornish AL, Freeman S, Forbes G, et al. (1998). "Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33". Blood 92 (6): 2123–32. PMID 9731071.
• Patel N, Brinkman-Van der Linden EC, Altmann SW, et al. (1999). "OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily". J. Biol. Chem. 274 (32): 22729–38. doi:10.1074/jbc.274.32.22729. PMID 10428856.
• Yousef GM, Ordon MH, Foussias G, Diamandis EP (2002). "Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes". Gene 286 (2): 259–70. doi:10.1016/S0378-1119(02)00432-8. PMID 11943481.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Erickson-Miller CL, Freeman SD, Hopson CB, et al. (2003). "Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes". Exp. Hematol. 31 (5): 382–8. doi:10.1016/S0301-472X(03)00046-8. PMID 12763136.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Avril T, Freeman SD, Attrill H, et al. (2005). "Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation". J. Biol. Chem. 280 (20): 19843–51. doi:10.1074/jbc.M502041200. PMID 15769739.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides". Biochemistry Mosc. 71 (5): 496–504. doi:10.1134/S0006297906050051. PMID 16732727.
• Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors". Leuk. Res. 31 (2): 211–20. doi:10.1016/j.leukres.2006.05.026. PMID 16828866.
• Angata T, Hayakawa T, Yamanaka M, et al. (2006). "Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates". FASEB J. 20 (12): 1964–73. doi:10.1096/fj.06-5800com. PMID 17012248.
• Zhuravleva MA, Trandem K, Sun PD (2007). "STRUCTURAL IMPLICATIONS OF SIGLEC-5 MEDIATED SIALO-GLYCAN RECOGNITION". J. Mol. Biol. 375 (2): 437–47. doi:10.1016/j.jmb.2007.10.009. PMC 2245879. PMID 18022638.