CD300A

CD300a molecule
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2Q87​
Identifiers
Symbols	CD300A ; CLM-8; CMRF-35-H9; CMRF-35H; CMRF35-H; CMRF35-H9; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC1/IRC2; IRC2; IRp60
External IDs	OMIM: 606790 MGI: 2443411 HomoloGene: 48514 GeneCards: CD300A Gene
Gene ontology Molecular function • phosphatidylserine binding • protein binding • phosphatidylethanolamine binding • signaling receptor activity Cellular component • plasma membrane • membrane • integral component of membrane • extracellular exosome Biological process • immune system process • cell adhesion • signal transduction • negative regulation of B cell proliferation • positive regulation of phosphoprotein phosphatase activity • negative regulation of mast cell activation involved in immune response • negative regulation of mast cell degranulation • negative regulation of MAP kinase activity • negative regulation of fibroblast proliferation • regulation of T cell receptor signaling pathway • negative regulation of B cell receptor signaling pathway • negative regulation of NK T cell activation • negative regulation of phagocytosis, engulfment • negative regulation of neutrophil activation • negative regulation of eosinophil activation • negative regulation of activation of JAK2 kinase activity • negative regulation of eosinophil migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11314	217303
Ensembl	ENSG00000167851	ENSMUSG00000034652
UniProt	Q9UGN4	Q6SJQ0
RefSeq (mRNA)	NM_001256841	NM_170758
RefSeq (protein)	NP_001243770	NP_739564
Location (UCSC)	Chr 17: 74.47 – 74.48 Mb	Chr 11: 114.89 – 114.9 Mb
PubMed search

CD300A (Cluster of Differentiation 300A) is a human gene.^[1]

The CMRF35 antigen (CMRF35A; MIM 606786), which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes. CMRF35H is recognized by the same antibody and is distinct from CMRF35 (Green et al., 1998).[supplied by OMIM]^[1]

References

1. "Entrez Gene: CD300A CD300a molecule".

See also

• Cluster of differentiation

Further reading

• Clark GJ, Fitzpatrick S, Kuo B; et al. (2003). "CMRF-35A, CMRF-35H: potential new CD.". J. Biol. Regul. Homeost. Agents 16 (3): 233–5. PMID 12456026.
• Alvarez Y, Tang X, Coligan JE, Borrego F (2007). "The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling.". Mol. Immunol. 45 (1): 253–8. doi:10.1016/j.molimm.2007.05.006. PMC 2000843. PMID 17588661.
• Bachelet I, Munitz A, Moretta A; et al. (2006). "The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells.". J. Immunol. 175 (12): 7989–95. doi:10.4049/jimmunol.175.12.7989. PMID 16339535.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark GJ, Green BJ, Hart DN (2000). "The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17.". Tissue Antigens 55 (2): 101–9. doi:10.1034/j.1399-0039.2000.550201.x. PMID 10746781.
• Cantoni C, Bottino C, Augugliaro R; et al. (1999). "Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells.". Eur. J. Immunol. 29 (10): 3148–59. doi:10.1002/(SICI)1521-4141(199910)29:10<3148::AID-IMMU3148>3.0.CO;2-L. PMID 10540326.
• Green BJ, Clark GJ, Hart DN (1998). "The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor.". Int. Immunol. 10 (7): 891–9. doi:10.1093/intimm/10.7.891. PMID 9701027.
• Jackson DG, Hart DN, Starling G, Bell JI (1992). "Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor.". Eur. J. Immunol. 22 (5): 1157–63. doi:10.1002/eji.1830220508. PMID 1349532.

External links

• CD300A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• CD300a, Bernholtz - The Possible End to Asthma - The Future of Things article

This article incorporates text from the United States National Library of Medicine, which is in the public domain.