ITGAD

Integrin, alpha D
Identifiers
Symbols	ITGAD ; ADB2; CD11D
External IDs	OMIM: 602453 MGI: 3578624 HomoloGene: 56919 GeneCards: ITGAD Gene
Gene ontology Molecular function • metal ion binding Cellular component • plasma membrane • integrin complex • cell surface Biological process • immune response • integrin-mediated signaling pathway • extracellular matrix organization • heterotypic cell-cell adhesion • activated T cell proliferation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3681	381924
Ensembl	ENSG00000156886	ENSMUSG00000070369
UniProt	Q13349	Q3V0T4
RefSeq (mRNA)	NM_005353	NM_001029872
RefSeq (protein)	NP_005344	NP_001025043
Location (UCSC)	Chr 16: 31.39 – 31.43 Mb	Chr 7: 128.15 – 128.22 Mb
PubMed search

Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene.^[1][2][3]

References

1. Wong DA, Davis EM, LeBeau M, Springer TA (Aug 1996). "Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit". Gene 171 (2): 291–4. doi:10.1016/0378-1119(95)00869-1. PMID 8666289.
2. Shelley CS, Da Silva N, Georgakis A, Chomienne C, Arnaout MA (Aug 1998). "Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb". Genomics 49 (2): 334–6. doi:10.1006/geno.1998.5232. PMID 9598326.
3. "Entrez Gene: ITGAD integrin, alpha D".

Further reading

• Van der Vieren M, Le Trong H, Wood CL, et al. (1996). "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3.". Immunity 3 (6): 683–90. doi:10.1016/1074-7613(95)90058-6. PMID 8777714.
• Grayson MH, Van der Vieren M, Sterbinsky SA, et al. (1999). "alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1).". J. Exp. Med. 188 (11): 2187–91. doi:10.1084/jem.188.11.2187. PMC 2212388. PMID 9841932.
• Van der Vieren M, Crowe DT, Hoekstra D, et al. (1999). "The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1.". J. Immunol. 163 (4): 1984–90. PMID 10438935.
• Noti JD, Johnson AK, Dillon JD (2000). "Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3.". J. Biol. Chem. 275 (12): 8959–69. doi:10.1074/jbc.275.12.8959. PMID 10722744.
• Noti JD (2003). "Expression of the myeloid-specific leukocyte integrin gene CD11d during macrophage foam cell differentiation and exposure to lipoproteins.". Int. J. Mol. Med. 10 (6): 721–7. doi:10.3892/ijmm.10.6.721. PMID 12429998.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Noti JD, Johnson AK, Dillon JD (2005). "The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells.". J. Biol. Chem. 280 (5): 3449–57. doi:10.1074/jbc.M412627200. PMID 15561714.

External links

• ITGAD Info with links in the Cell Migration Gateway