Decoy receptor 2

Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
Identifiers
Symbols	TNFRSF10D ; CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD
External IDs	OMIM: 603614 HomoloGene: 136778 GeneCards: TNFRSF10D Gene
Gene ontology Molecular function • transmembrane signaling receptor activity • TRAIL binding Cellular component • integral component of membrane Biological process • apoptotic process • signal transduction • negative regulation of apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8793	n/a
Ensembl	ENSG00000173530	n/a
UniProt	Q9UBN6	n/a
RefSeq (mRNA)	NM_003840	n/a
RefSeq (protein)	NP_003831	n/a
Location (UCSC)	Chr 8: 23.14 – 23.16 Mb	n/a
PubMed search		n/a

Decoy receptor 2 (DCR2), also known as TRAIL receptor 4 (TRAILR4) and tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), is a human cell surface receptor of the TNF-receptor superfamily.^[1][2][3]

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.^[3]

References

1. Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A (Feb 1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr Biol 7 (12): 1003–6. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840.
2. Pan G, Ni J, Yu G, Wei YF, Dixit VM (Apr 1998). "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling". FEBS Lett 424 (1-2): 41–5. doi:10.1016/S0014-5793(98)00135-5. PMID 9537512.
3. "Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain".

Further reading

• Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72. doi:10.1038/sj.cr.7290236. PMID 15538968.
• Degli-Esposti MA, Dougall WC, Smolak PJ; et al. (1998). "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain.". Immunity 7 (6): 813–20. doi:10.1016/S1074-7613(00)80399-4. PMID 9430226.
• Phillips TA, Ni J, Pan G; et al. (1999). "TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege.". J. Immunol. 162 (10): 6053–9. PMID 10229846.
• Zhang XD, Franco AV, Nguyen T; et al. (2000). "Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells.". J. Immunol. 164 (8): 3961–70. doi:10.4049/jimmunol.164.8.3961. PMID 10754286.
• Daigle I, Simon HU (2001). "Alternative functions for TRAIL receptors in eosinophils and neutrophils.". Swiss medical weekly : official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology 131 (17-18): 231–7. PMID 11420819.
• Dörr J, Bechmann I, Waiczies S; et al. (2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain.". J. Neurosci. 22 (4): RC209. PMID 11844843.
• Sun SY, Yue P, Chen X; et al. (2002). "The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells.". Cancer Res. 62 (8): 2430–6. PMID 11956107.
• Matysiak M, Jurewicz A, Jaskolski D, Selmaj K (2002). "TRAIL induces death of human oligodendrocytes isolated from adult brain.". Brain 125 (Pt 11): 2469–80. doi:10.1093/brain/awf254. PMID 12390973.
• Robertson NM, Zangrilli JG, Steplewski A; et al. (2003). "Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival.". J. Immunol. 169 (10): 5986–96. doi:10.4049/jimmunol.169.10.5986. PMID 12421985.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ou D, Metzger DL, Wang X; et al. (2003). "TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction.". Diabetologia 45 (12): 1678–88. doi:10.1007/s00125-002-0926-2. PMID 12488957.
• Hasel C, Dürr S, Rau B; et al. (2003). "In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas.". Lab. Invest. 83 (6): 825–36. doi:10.1097/01.lab.0000073126.56932.46. PMID 12808117.
• Kotelkin A, Prikhod'ko EA, Cohen JI; et al. (2003). "Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand.". J. Virol. 77 (17): 9156–72. doi:10.1128/JVI.77.17.9156-9172.2003. PMC 187410. PMID 12915532.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Shivapurkar N, Toyooka S, Toyooka KO; et al. (2004). "Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types.". Int. J. Cancer 109 (5): 786–92. doi:10.1002/ijc.20041. PMID 14999791.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.