CD32

Fc fragment of IgG, low affinity IIa, receptor (CD32)
Identifiers
Symbol	FCGR2A
Alt. symbols	FCG2, FCGR2A1, FCGR2
Entrez	2212
HUGO	3616
OMIM	146790
RefSeq	NM_021642
UniProt	P12318
Other data
Locus	Chr. 1 q23

Fc fragment of IgG, low affinity IIb, receptor (CD32)
Crystal structure of the human fcgamma-receptor IIb ectodomain (CD32).[1]
Identifiers
Symbol	FCGR2B
Alt. symbols	FCG2, FCGR2
Entrez	2213
HUGO	3618
OMIM	604590
RefSeq	NM_004001
UniProt	P31994
Other data
Locus	Chr. 1 q23

Fc fragment of IgG, low affinity IIc, receptor for (CD32)
Identifiers
Symbol	FCGR2C
Entrez	9103
HUGO	15626
RefSeq	NM_201563
UniProt	P31995
Other data
Locus	Chr. 1 q23

CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling.

It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body.^[2]

Monoclonal antibodies can distinguish between CD32A and CD32B.^[3]

References

1. PDB: 2FCB​; Sondermann P, Huber R, Jacob U. (March 1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.". EMBO J. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577.; rendered via PyMOL.
2. Coico, R., Sunshine, G., and Benjamin, E. (2003). "Immunology: A Short Course" p.97.
3. Veri MC, Gorlatov S, Li H; et al. (2007). "Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization". Immunology 121 (3): 392–404. doi:10.1111/j.1365-2567.2007.02588.x. PMC 2265948. PMID 17386079.

External links

• CD32 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)