CD247

CD247 molecule
PDB rendering based on 2hac.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1TCE​, 1YGR​, 2HAC​, 2OQ1​, 3IK5​, 3IOZ​
Identifiers
Symbols	CD247 ; CD3-ZETA; CD3H; CD3Q; CD3Z; IMD25; T3Z; TCRZ
External IDs	OMIM: 186780 MGI: 88334 HomoloGene: 12818 GeneCards: CD247 Gene
Gene ontology Molecular function • transmembrane signaling receptor activity • protein binding • identical protein binding • protein homodimerization activity Cellular component • cytoplasm • plasma membrane • integral component of membrane • T cell receptor complex • alpha-beta T cell receptor complex Biological process • viral process • T cell costimulation • Fc-gamma receptor signaling pathway involved in phagocytosis • innate immune response • regulation of defense response to virus by virus • regulation of immune response • T cell receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	919	12503
Ensembl	ENSG00000198821	ENSMUSG00000005763
UniProt	P20963	P24161
RefSeq (mRNA)	NM_000734	NM_001113391
RefSeq (protein)	NP_000725	NP_001106862
Location (UCSC)	Chr 1: 167.43 – 167.52 Mb	Chr 1: 165.79 – 165.88 Mb
PubMed search

T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.^[1]

Genomics

The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The gene is 87,896 bases in length. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.

Function

T-cell receptor zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[2]

Interactions

CD247 has been shown to interact with Janus kinase 3^[3] and Protein unc-119 homolog.^[4]

See also

• Cluster of differentiation
• ZAP70

References

1. Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ, Klausner RD (December 1988). "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9709–13. doi:10.1073/pnas.85.24.9709. PMC 282845. PMID 2974162.
2. "Entrez Gene: CD247 CD247 molecule".
3. Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T (Jul 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. doi:10.1074/jbc.M011363200. PMID 11349123.
4. Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem.20030589. PMC 2211793. PMID 14757743.

Further reading

• Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
• Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.". J. Biosci. 28 (3): 323–35. doi:10.1007/BF02970151. PMID 12734410.
• Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects.". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.

External links

• CD247 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)