CD49a

Integrin, alpha 1

PDB rendering based on 1ck4.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1PT6, 1QC5, 1QCY, 2L8S, 2M32, 4A0Q

Identifiers

Symbols

ITGA1 ; CD49a; VLA1

External IDs

OMIM: 192968 MGI: 96599 HomoloGene: 57137 ChEMBL: 3682 GeneCards: ITGA1 Gene

Gene ontology
Molecular function	• receptor binding • protein binding • collagen binding • protein phosphatase binding • metal ion binding • collagen binding involved in cell-matrix adhesion
Cellular component	• acrosomal vesicle • plasma membrane • focal adhesion • integrin complex • external side of plasma membrane • cell surface • membrane • integrin alpha1-beta1 complex • neuron projection • perikaryon • membrane raft • basal part of cell • extracellular exosome
Biological process	• activation of MAPK activity • muscle contraction • cell-matrix adhesion • integrin-mediated signaling pathway • axon guidance • blood coagulation • negative regulation of cell proliferation • extracellular matrix organization • neutrophil chemotaxis • positive regulation of phosphoprotein phosphatase activity • negative regulation of epidermal growth factor receptor signaling pathway • vasodilation • positive regulation of neuron apoptotic process • cellular extravasation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
52.79 – 52.96 Mb

Chr 13:
114.96 – 115.1 Mb

PubMed search

CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.^[1]

References

↑ "Entrez Gene: ITGA1 integrin, alpha 1".

Virtanen I, Korhonen M, Kariniemi AL; et al. (1991). "Integrins in human cells and tumors.". Cell Differ. Dev. 32 (3): 215–27. doi:10.1016/0922-3371(90)90034-T. PMID 2099238.
Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis.". Atherosclerosis 166 (1): 1–11. doi:10.1016/S0021-9150(01)00766-3. PMID 12482545.
Clover J, Dodds RA, Gowen M (1992). "Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture.". J. Cell. Sci. 103 (1): 267–71. PMID 1429908.
Bodary SC, McLean JW (1990). "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.". J. Biol. Chem. 265 (11): 5938–41. PMID 1690718.
Sonnenberg A, Linders CJ, Modderman PW; et al. (1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.". J. Cell Biol. 110 (6): 2145–55. doi:10.1083/jcb.110.6.2145. PMC 2116116. PMID 1693624.
Belkin VM, Belkin AM, Dol'nikova AE; et al. (1992). "[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles]". Biokhimiia 56 (12): 2198–206. PMID 1807406.
Bank I, Roth D, Book M; et al. (1991). "Expression and functions of very late antigen 1 in inflammatory joint diseases.". J. Clin. Immunol. 11 (1): 29–38. doi:10.1007/BF00918792. PMID 1827128.
Tabibzadeh S (1990). "Evidence of T-cell activation and potential cytokine action in human endometrium.". J. Clin. Endocrinol. Metab. 71 (3): 645–9. doi:10.1210/jcem-71-3-645. PMID 2144294.
Tawil NJ, Houde M, Blacher R; et al. (1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells.". Biochemistry 29 (27): 6540–4. doi:10.1021/bi00479a028. PMC 2710132. PMID 2169872.
Belkin VM, Belkin AM, Koteliansky VE (1990). "Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development.". J. Cell Biol. 111 (5 Pt 1): 2159–70. doi:10.1083/jcb.111.5.2159. PMC 2116325. PMID 2229189.
MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine.". J. Clin. Pathol. 43 (4): 313–5. doi:10.1136/jcp.43.4.313. PMC 502365. PMID 2341567.
Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3239–43. doi:10.1073/pnas.84.10.3239. PMC 304844. PMID 3033641.
Hemler ME, Huang C, Schwarz L (1987). "The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.". J. Biol. Chem. 262 (7): 3300–9. PMID 3546305.
Kono Y, Yang S, Letarte M, Roberts EA (1996). "Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system.". Exp. Cell Res. 221 (2): 478–85. doi:10.1006/excr.1995.1399. PMID 7493648.
Eglinton BA, Roberton DM, Cummins AG (1995). "Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk.". Immunol. Cell Biol. 72 (4): 306–13. doi:10.1038/icb.1994.46. PMID 7806264.
Salter DM, Godolphin JL, Gourlay MS (1995). "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees.". J. Histochem. Cytochem. 43 (4): 447–57. doi:10.1177/43.4.7897185. PMID 7897185.
Pfaff M, Aumailley M, Specks U; et al. (1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI.". Exp. Cell Res. 206 (1): 167–76. doi:10.1006/excr.1993.1134. PMID 8387021.
Briesewitz R, Epstein MR, Marcantonio EE (1993). "Expression of native and truncated forms of the human integrin alpha 1 subunit.". J. Biol. Chem. 268 (4): 2989–96. PMID 8428973.
Langholz O, Röckel D, Mauch C; et al. (1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins.". J. Cell Biol. 131 (6 Pt 2): 1903–15. doi:10.1083/jcb.131.6.1903. PMC 2120685. PMID 8557756.

PDB gallery

1ck4: CRYSTAL STRUCTURE OF RAT A1B1 INTEGRIN I-DOMAIN.

1mhp: Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody

1pt6: I domain from human integrin alpha1-beta1

1qc5: I Domain from Integrin Alpha1-Beta1

1qcy: THE CRYSTAL STRUCTURE OF THE I-DOMAIN OF HUMAN INTEGRIN ALPHA1BETA1

2b2x: VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab

External links

CD49a antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
ITGA1 Info with links in the Cell Migration Gateway

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Integrins

Alpha

Beta

Dimers

Cytoadhesin receptor:	Integrin alpha6beta4 Glycoprotein IIb/IIIa ITGA2B+ITGB3

Fibrinogen receptor:	Macrophage-1 antigen CD11b+CD18

Fibronectin receptor:	Integrin alpha2beta1 Integrin alpha4beta1 Integrin alpha5beta1

Leukocyte-adhesion receptor:	LFA-1 CD11a+CD18 Macrophage-1 antigen CD11b+CD18 Integrin alphaXbeta2 CD11c+CD18

Very late antigen receptor:	Integrin alpha1beta1 Integrin alpha2beta1 Integrin alpha3beta1 VLA-4 CD49d+CD29 Alpha-5 beta-1 Integrin alpha6beta1

Vitronectin receptor:	Alpha-v beta-3 Alpha-v beta-5

see also cell surface receptor deficiencies

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CD49a

References

Further reading

External links