Integrin, beta 5

Integrin, beta 5
Identifiers
Symbols	ITGB5 ; FLJ26658
External IDs	OMIM: 147561 MGI: 96614 HomoloGene: 20511 ChEMBL: 2600 GeneCards: ITGB5 Gene
Gene ontology Molecular function • receptor activity • integrin binding • protein binding Cellular component • plasma membrane • focal adhesion • cell surface • cell leading edge • integrin alphav-beta5 complex • receptor complex • phagocytic vesicle • extracellular exosome Biological process • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • muscle contraction • cell-matrix adhesion • transforming growth factor beta receptor signaling pathway • integrin-mediated signaling pathway • extracellular matrix organization • endodermal cell differentiation • antigen processing and presentation of exogenous peptide antigen via MHC class I • stress fiber assembly • epithelial cell-cell adhesion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3693	16419
Ensembl	ENSG00000082781	ENSMUSG00000022817
UniProt	P18084	O70309
RefSeq (mRNA)	NM_002213	NM_001145884
RefSeq (protein)	NP_002204	NP_001139356
Location (UCSC)	Chr 3: 124.76 – 124.9 Mb	Chr 16: 33.83 – 33.95 Mb
PubMed search

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.^[1][2]

Interactions

Integrin, beta 5 has been shown to interact with PTK2,^[3] Annexin A5^[4] and PAK4.^[5]

Clinical significance

Research

Elevated levels of ITGB5 have been found in patients suffering from autosomal dominant osteopetrosis type II, a rare disease of bones. ^[6]

References

1. McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem 265 (28): 17126–31. PMID 2211615.
2. "Entrez Gene: ITGB5 integrin, beta 5".
3. Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; Huang Xiaozhu Z; Sheppard Dean; Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. (United States) 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607.
4. Cardó-Vila, Marina; Arap Wadih; Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell (United States) 11 (5): 1151–62. doi:10.1016/S1097-2765(03)00138-2. ISSN 1097-2765. PMID 12769841.
5. Zhang, Hongquan; Li Zhilun; Viklund Eva-Karin; Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. (United States) 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231. PMID 12356872.
6. Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology.". Lab Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069.

Further reading

• Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization.". BioEssays 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216.
• Smith JW, Vestal DJ, Irwin SV, et al. (1990). "Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin.". J. Biol. Chem. 265 (19): 11008–13. PMID 1694173.
• Adams JC, Watt FM (1991). "Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes.". J. Cell Biol. 115 (3): 829–41. doi:10.1083/jcb.115.3.829. PMC 2289188. PMID 1918165.
• Ramaswamy H, Hemler ME (1990). "Cloning, primary structure and properties of a novel human integrin beta subunit.". EMBO J. 9 (5): 1561–8. PMC 551850. PMID 2328726.
• Suzuki S, Huang ZS, Tanihara H (1990). "Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit.". Proc. Natl. Acad. Sci. U.S.A. 87 (14): 5354–8. doi:10.1073/pnas.87.14.5354. PMC 54322. PMID 2371275.
• Hu DD, Lin EC, Kovach NL, et al. (1995). "A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5.". J. Biol. Chem. 270 (44): 26232–8. doi:10.1074/jbc.270.44.26232. PMID 7592829.
• Vogel BE, Lee SJ, Hildebrand A, et al. (1993). "A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin.". J. Cell Biol. 121 (2): 461–8. doi:10.1083/jcb.121.2.461. PMC 2200091. PMID 7682219.
• Pasqualini R, Bodorova J, Ye S, Hemler ME (1993). "A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies.". J. Cell. Sci. 105 (1): 101–11. PMID 7689573.
• Lafrenie RM, Wahl LM, Epstein JS, et al. (1996). "HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes.". Journal of Immunology 157 (3): 974–7. PMID 8757599.
• Rabb H, Barroso-Vicens E, Adams R, et al. (1997). "Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney.". Am. J. Nephrol. 16 (5): 402–8. doi:10.1159/000169032. PMID 8886177.
• Liliental J, Chang DD (1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit.". J. Biol. Chem. 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. PMID 9442085.
• Memmo LM, McKeown-Longo P (1998). "The alphavbeta5 integrin functions as an endocytic receptor for vitronectin.". J. Cell. Sci. 111 (4): 425–33. PMID 9443892.
• Zhang H, Tan SM, Lu J (1998). "cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing.". Biochem. J. 331 (2): 631–7. PMC 1219398. PMID 9531507.
• Barillari G, Sgadari C, Palladino C, et al. (1999). "Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin.". Journal of Immunology 163 (4): 1929–35. PMID 10438928.
• Carriero MV, Del Vecchio S, Capozzoli M, et al. (1999). "Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer.". Cancer Res. 59 (20): 5307–14. PMID 10537314.
• Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein.". J. Cell Biol. 147 (5): 1073–84. doi:10.1083/jcb.147.5.1073. PMC 2169340. PMID 10579726.
• Cirulli V, Beattie GM, Klier G, et al. (2000). "Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells.". J. Cell Biol. 150 (6): 1445–60. doi:10.1083/jcb.150.6.1445. PMC 2150716. PMID 10995448.
• Albert ML, Kim JI, Birge RB (2001). "alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells.". Nat. Cell Biol. 2 (12): 899–905. doi:10.1038/35046549. PMID 11146654.
• Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin.". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000.4155. PMID 11162558.
• Niu JK, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN. (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion.". Eur J Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID 18090124.

External links

• ITGB5 Info with links in the Cell Migration Gateway