ITGA11

Integrin, alpha 11
Identifiers
Symbols	ITGA11 ; HsT18964
External IDs	OMIM: 604789 MGI: 2442114 HomoloGene: 8151 ChEMBL: 5883 GeneCards: ITGA11 Gene
Gene ontology Molecular function • collagen binding • collagen receptor activity • metal ion binding • collagen binding involved in cell-matrix adhesion Cellular component • plasma membrane • focal adhesion • integrin complex • membrane • integrin alpha11-beta1 complex Biological process • osteoblast differentiation • substrate-dependent cell migration • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • muscle organ development • extracellular matrix organization • cell adhesion mediated by integrin • collagen-activated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22801	319480
Ensembl	ENSG00000137809	ENSMUSG00000032243
UniProt	Q9UKX5	Q7TQC3
RefSeq (mRNA)	NM_001004439	NM_176922
RefSeq (protein)	NP_001004439	NP_795896
Location (UCSC)	Chr 15: 68.3 – 68.43 Mb	Chr 9: 62.68 – 62.78 Mb
PubMed search

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene.^[1][2]

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.^[2]

According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus.^[3]

References

1. Lehnert K, Ni J, Leung E, Gough SM, Weaver A, Yao WP, Liu D, Wang SX, Morris CM, Krissansen GW (Nov 1999). "Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11)". Genomics 60 (2): 179–87. doi:10.1006/geno.1999.5909. PMID 10486209.
2. "Entrez Gene: ITGA11 integrin, alpha 11".
3. Byström B, Carracedo S, Behndig AB, Gullberg D, Pedrosa-Domellof F (June 2009). "{alpha}11 integrin in the human cornea-importance in development and disease". Invest. Ophthalmol. Vis. Sci. 50 (11): 5044–53. doi:10.1167/iovs.08-3261. PMID 19516006.

Further reading

• Zhu CQ, Popova SN, Brown ER, et al. (2007). "Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells.". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11754–9. doi:10.1073/pnas.0703040104. PMC 1913903. PMID 17600088.
• Leomil Coelho LF, Mota BE, Sales PC, et al. (2006). "Integrin alpha 11 is a novel type I interferon stimulated gene.". Cytokine 33 (6): 352–61. doi:10.1016/j.cyto.2006.03.007. PMID 16697656.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang WM, Kapyla J, Puranen JS, et al. (2003). "alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens.". J. Biol. Chem. 278 (9): 7270–7. doi:10.1074/jbc.M210313200. PMID 12496264.
• Zhang WM, Popova SN, Bergman C, et al. (2003). "Analysis of the human integrin alpha11 gene (ITGA11) and its promoter.". Matrix Biol. 21 (6): 513–23. doi:10.1016/S0945-053X(02)00054-9. PMID 12392762.
• Tiger CF, Fougerousse F, Grundström G, et al. (2001). "alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells.". Dev. Biol. 237 (1): 116–29. doi:10.1006/dbio.2001.0363. PMID 11518510.
• Velling T, Kusche-Gullberg M, Sejersen T, Gullberg D (1999). "cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues.". J. Biol. Chem. 274 (36): 25735–42. doi:10.1074/jbc.274.36.25735. PMID 10464311.

External links

• ITGA11 Info with links in the Cell Migration Gateway