ITGA6

Integrin, alpha 6
Identifiers
Symbols	ITGA6 ; CD49f; ITGA6B; VLA-6
External IDs	OMIM: 147556 MGI: 96605 HomoloGene: 20091 ChEMBL: 3716 GeneCards: ITGA6 Gene
Gene ontology Molecular function • integrin binding • protein binding • metal ion binding Cellular component • basement membrane • plasma membrane • focal adhesion • integrin complex • external side of plasma membrane • basal plasma membrane • cell surface • hemidesmosome Biological process • cell-substrate junction assembly • cell-matrix adhesion • integrin-mediated signaling pathway • blood coagulation • ectodermal cell differentiation • positive regulation of cell-cell adhesion • extracellular matrix organization • hemidesmosome assembly • cell-substrate adhesion • cellular response to extracellular stimulus • cell adhesion mediated by integrin • cell junction assembly • nail development • positive regulation of phosphorylation • positive regulation of apoptotic process • skin development • positive regulation of transcription from RNA polymerase II promoter • filopodium assembly • digestive tract development • brown fat cell differentiation • leukocyte migration • renal system development • amelogenesis • negative regulation of extrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3655	16403
Ensembl	ENSG00000091409	ENSMUSG00000027111
UniProt	P23229	Q61739
RefSeq (mRNA)	NM_000210	NM_001277970
RefSeq (protein)	NP_000201	NP_001264899
Location (UCSC)	Chr 2: 172.43 – 172.51 Mb	Chr 2: 71.75 – 71.86 Mb
PubMed search

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.^[1]

Interactions

ITGA6 has been shown to interact with TSPAN4^[2] and GIPC1.^[3]

See also

• Cluster of differentiation
• Integrins

References

1. "Entrez Gene: ITGA6 integrin, alpha 6".
2. Tachibana, I; Bodorova J; Berditchevski F; Zutter M M; Hemler M E (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. ISSN 0021-9258. PMID 9360996.
3. Tani, T T; Mercurio A M (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. (United States) 276 (39): 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315.

Further reading

• Lipscomb EA, Mercurio AM (2006). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression.". Cancer Metastasis Rev. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729.

External links

• CD49f Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• ITGA6 Info with links in the Cell Migration Gateway