CD86

CD86 molecule
PDB rendering based on 1i85.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1I85​, 1NCN​
Identifiers
Symbols	CD86 ; B7-2; B7.2; B70; CD28LG2; LAB72
External IDs	OMIM: 601020 MGI: 101773 HomoloGene: 10443 GeneCards: CD86 Gene
Gene ontology Molecular function • receptor activity • receptor binding • protein binding • coreceptor activity Cellular component • plasma membrane • external side of plasma membrane • cell surface • integral component of membrane • intracellular membrane-bounded organelle • extracellular exosome Biological process • response to yeast • toll-like receptor signaling pathway • adaptive immune response • T cell proliferation involved in immune response • negative regulation of T cell anergy • immune response • epidermal growth factor receptor signaling pathway • cell-cell signaling • aging • positive regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • viral process • T cell costimulation • response to interferon-gamma • Fc-epsilon receptor signaling pathway • positive regulation of activated T cell proliferation • T cell activation • B cell activation • response to drug • myeloid dendritic cell differentiation • positive regulation of lymphotoxin A biosynthetic process • positive regulation of interleukin-2 biosynthetic process • innate immune response • positive regulation of interleukin-4 biosynthetic process • positive regulation of T-helper 2 cell differentiation • positive regulation of transcription, DNA-templated • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • defense response to virus • cellular response to lipopolysaccharide • cellular response to metal ion • cellular response to cytokine stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	942	12524
Ensembl	ENSG00000114013	ENSMUSG00000022901
UniProt	P42081	P42082
RefSeq (mRNA)	NM_001206924	NM_019388
RefSeq (protein)	NP_001193853	NP_062261
Location (UCSC)	Chr 3: 122.06 – 122.12 Mb	Chr 16: 36.6 – 36.67 Mb
PubMed search

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.^[1] Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.^[2]

See also

• Cluster of differentiation
• CD80
• CD28
• CTLA-4
• List of human clusters of differentiation for a list of CD molecules

References

1. Chen C, Gault A, Shen L, Nabavi N (May 1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol. 152 (10): 4929–36. PMID 7513726.
2. "Entrez Gene: CD86 CD86 molecule".

Further reading

• Davila S, Froeling FE, Tan A; et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine.". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Csillag A, Boldogh I, Pazmandi K; et al. (2010). "Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions.". J. Immunol. 184 (5): 2377–85. doi:10.4049/jimmunol.0803938. PMC 3028537. PMID 20118277.
• Bossé Y, Lemire M, Poon AH; et al. (2009). "Asthma and genes encoding components of the vitamin D pathway". Respir. Res. 10: 98. doi:10.1186/1465-9921-10-98. PMC 2779188. PMID 19852851.
• Mosbruger TL, Duggal P, Goedert JJ; et al. (2010). "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus". J. Infect. Dis. 201 (9): 1371–80. doi:10.1086/651606. PMC 2853721. PMID 20331378.
• Bugeon L, Dallman MJ (2000). "Costimulation of T cells". Am. J. Respir. Crit. Care Med. 162 (4 Pt 2): S164–8. doi:10.1164/ajrccm.162.supplement_3.15tac5. PMID 11029388.
• Pan XM, Gao LB, Liang WB; et al. (2010). "CD86 +1057 G/A polymorphism and the risk of colorectal cancer". DNA Cell Biol. 29 (7): 381–6. doi:10.1089/dna.2009.1003. PMID 20380573.
• Dalla-Costa R, Pincerati MR, Beltrame MH; et al. (2010). "Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to pemphigus foliaceus". Hum. Immunol. 71 (8): 809–17. doi:10.1016/j.humimm.2010.04.001. PMID 20433886.
• Talmud PJ, Drenos F, Shah S; et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Carreño LJ, Pacheco R, Gutierrez MA; et al. (2009). "Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells". Immunology 128 (3): 334–41. doi:10.1111/j.1365-2567.2009.03138.x. PMC 2770681. PMID 20067533.
• Koyasu S (2003). "The role of PI3K in immune cells". Nat. Immunol. 4 (4): 313–9. doi:10.1038/ni0403-313. PMID 12660731.
• Kim SH, Lee JE, Kim SH; et al. (2009). "Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions". Clin. Exp. Allergy 39 (12): 1852–6. doi:10.1111/j.1365-2222.2009.03336.x. PMID 19735272.
• Liu Y, Liang WB, Gao LB; et al. (2010). "CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease". Hum. Immunol. 71 (11): 1141–6. doi:10.1016/j.humimm.2010.08.007. PMID 20732370.
• Ma XN, Wang X, Yan YY; et al. (2010). "Absence of association between CD86 +1057G/A polymorphism and coronary artery disease". DNA Cell Biol. 29 (6): 325–8. doi:10.1089/dna.2009.0987. PMID 20230296.
• Ishizaki Y, Yukaya N, Kusuhara K; et al. (2010). "PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis". Human Genetics 127 (4): HASH(0x31b6c40). doi:10.1007/s00439-009-0781-z. PMID 20066438.
• Chang TT, Kuchroo VK, Sharpe AH (2002). "Role of the B7-CD28/CTLA-4 pathway in autoimmune disease". Curr. Dir. Autoimmun. 5: 113–30. doi:10.1159/000060550. PMID 11826754.
• Grujic M, Bartholdy C, Remy M; et al. (2010). "The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus". J. Immunol. 185 (3): 1730–43. doi:10.4049/jimmunol.0903894. PMID 20601595.
• Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB J. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.
• Schuurhof A, Bont L, Siezen CL; et al. (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". Pediatr. Pulmonol. 45 (6): 608–13. doi:10.1002/ppul.21229. PMID 20503287.
• Bailey SD, Xie C, Do R; et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Radziewicz H, Ibegbu CC, Hon H; et al. (2010). "Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling". J. Immunol. 184 (5): 2410–22. doi:10.4049/jimmunol.0902994. PMC 2924663. PMID 20100932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.