ADAM8

ADAM metallopeptidase domain 8
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4DD8​
Identifiers
Symbols	ADAM8 ; CD156; CD156a; MS2
External IDs	OMIM: 602267 MGI: 107825 HomoloGene: 74384 GeneCards: ADAM8 Gene
EC number	3.4.24.-
Gene ontology Molecular function • metalloendopeptidase activity • calcium ion binding • protein binding • metallopeptidase activity • zinc ion binding • protein self-association • cell adhesion molecule binding Cellular component • podosome • cytoplasm • plasma membrane • integral component of plasma membrane • cell surface • phagolysosome • dense core granule membrane • specific granule • tertiary granule • alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex • alpha9-beta1 integrin-ADAM8 complex Biological process • cell morphogenesis • angiogenesis • leukocyte migration involved in inflammatory response • positive regulation of acute inflammatory response • proteolysis • inflammatory response • positive regulation of protein processing • single organismal cell-cell adhesion • regulation of cell-cell adhesion • extracellular matrix disassembly • extracellular matrix organization • positive regulation of T cell differentiation in thymus • activation of MAPK activity involved in innate immune response • negative regulation of neuron apoptotic process • positive regulation of bone resorption • positive regulation of cell adhesion • lymphocyte chemotaxis • positive regulation of protein secretion • positive regulation of membrane protein ectodomain proteolysis • positive regulation of NF-kappaB transcription factor activity • positive regulation of protein kinase B signaling • positive regulation of thymocyte apoptotic process • cellular response to hypoxia • positive regulation of tumor necrosis factor (ligand) superfamily member 11 production • positive regulation of neutrophil extravasation • positive regulation of fibronectin-dependent thymocyte migration • positive regulation of eosinophil migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	101	11501
Ensembl	ENSG00000151651	ENSMUSG00000025473
UniProt	P78325	Q05910
RefSeq (mRNA)	NM_001109	NM_001291066
RefSeq (protein)	NP_001100	NP_001277995
Location (UCSC)	Chr 10: 133.26 – 133.28 Mb	Chr 7: 139.98 – 139.99 Mb
PubMed search

A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.^[1][2]

Function

This gene encodes a member of the ADAM (a disintegrin and metalloproteinase domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.^[2]

See also

• Cluster of differentiation

References

1. Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (Apr 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482.
2. "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".

Further reading

• Yamamoto S, Higuchi Y, Yoshiyama K, Shimizu E, Kataoka M, Hijiya N, Matsuura K (Jun 1999). "ADAM family proteins in the immune system". Immunology Today 20 (6): 278–84. doi:10.1016/S0167-5699(99)01464-4. PMID 10354553.
• Schlomann U, Rathke-Hartlieb S, Yamamoto S, Jockusch H, Bartsch JW (Nov 2000). "Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration". The Journal of Neuroscience 20 (21): 7964–71. PMID 11050116.
• Amour A, Knight CG, English WR, Webster A, Slocombe PM, Knäuper V, Docherty AJ, Becherer JD, Blobel CP, Murphy G (Jul 2002). "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs". FEBS Letters 524 (1-3): 154–8. doi:10.1016/S0014-5793(02)03047-8. PMID 12135759.
• Ishikawa N, Daigo Y, Yasui W, Inai K, Nishimura H, Tsuchiya E, Kohno N, Nakamura Y (Dec 2004). "ADAM8 as a novel serological and histochemical marker for lung cancer". Clinical Cancer Research 10 (24): 8363–70. doi:10.1158/1078-0432.CCR-04-1436. PMID 15623614.
• Foley SC, Mogas AK, Olivenstein R, Fiset PO, Chakir J, Bourbeau J, Ernst P, Lemière C, Martin JG, Hamid Q (Apr 2007). "Increased expression of ADAM33 and ADAM8 with disease progression in asthma". The Journal of Allergy and Clinical Immunology 119 (4): 863–71. doi:10.1016/j.jaci.2006.12.665. PMID 17339047.
• Gómez-Gaviro M, Domínguez-Luis M, Canchado J, Calafat J, Janssen H, Lara-Pezzi E, Fourie A, Tugores A, Valenzuela-Fernández A, Mollinedo F, Sánchez-Madrid F, Díaz-González F (Jun 2007). "Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding". Journal of Immunology 178 (12): 8053–63. doi:10.4049/jimmunol.178.12.8053. PMID 17548643.
• Valkovskaya N, Kayed H, Felix K, Hartmann D, Giese NA, Osinsky SP, Friess H, Kleeff J (2008). "ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer". Journal of Cellular and Molecular Medicine 11 (5): 1162–74. doi:10.1111/j.1582-4934.2007.00082.x. PMID 17979891.

External links

• The MEROPS online database for peptidases and their inhibitors: M12.208
• ADAM8 human gene location in the UCSC Genome Browser.
• ADAM8 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.