Interleukin 13 receptor, alpha 1

Rendering based on PDB 3BPN.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3BPN, 3BPO, 4HWB

Identifiers

Symbols

IL13RA1 ; CD213A1; CT19; IL-13Ra; NR4

External IDs

OMIM: 300119 MGI: 105052 HomoloGene: 1198 GeneCards: IL13RA1 Gene

Gene ontology
Molecular function	• cytokine receptor activity • protein binding
Cellular component	• plasma membrane • interleukin-13 receptor complex
Biological process	• cell surface receptor signaling pathway • cytokine-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
118.73 – 118.79 Mb

Chr X:
36.11 – 36.17 Mb

PubMed search

Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene.^[1]

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.^[1]

References

1 2 "Entrez Gene: IL13RA1 interleukin 13 receptor, alpha 1".

Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.". Science 269 (5231): 1737–40. doi:10.1126/science.7569905. PMID 7569905.
Aman MJ, Tayebi N, Obiri NI, et al. (1997). "cDNA cloning and characterization of the human interleukin 13 receptor alpha chain.". J. Biol. Chem. 271 (46): 29265–70. doi:10.1074/jbc.271.46.29265. PMID 8910586.
Miloux B, Laurent P, Bonnin O, et al. (1997). "Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex.". FEBS Lett. 401 (2-3): 163–6. doi:10.1016/S0014-5793(96)01462-7. PMID 9013879.
Zhang JG, Hilton DJ, Willson TA, et al. (1997). "Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains.". J. Biol. Chem. 272 (14): 9474–80. doi:10.1074/jbc.272.14.9474. PMID 9083087.
Orchansky PL, Kwan R, Lee F, Schrader JW (1999). "Characterization of the cytoplasmic domain of interleukin-13 receptor-alpha.". J. Biol. Chem. 274 (30): 20818–25. doi:10.1074/jbc.274.30.20818. PMID 10409622.
Osawa M, Miyoshi S, Copeland NG, et al. (2000). "Characterization of the mouse interleukin-13 receptor alpha1 gene.". Immunogenetics 51 (11): 974–81. doi:10.1007/s002510000225. PMID 11003391.
Umeshita-Suyama R, Sugimoto R, Akaiwa M, et al. (2000). "Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation.". Int. Immunol. 12 (11): 1499–509. doi:10.1093/intimm/12.11.1499. PMID 11058569.
Oshima Y, Puri RK (2001). "Characterization of a powerful high affinity antagonist that inhibits biological activities of human interleukin-13.". J. Biol. Chem. 276 (18): 15185–91. doi:10.1074/jbc.M010159200. PMID 11278629.
Kawakami M, Leland P, Kawakami K, Puri RK (2002). "Mutation and functional analysis of IL-13 receptors in human malignant glioma cells.". Oncol. Res. 12 (11-12): 459–67. doi:10.3727/096504001108747468. PMID 11939409.
Roy B, Bhattacharjee A, Xu B, et al. (2002). "IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats.". J. Leukoc. Biol. 72 (3): 580–9. PMID 12223527.
Andrews AL, Holloway JW, Puddicombe SM, et al. (2003). "Kinetic analysis of the interleukin-13 receptor complex.". J. Biol. Chem. 277 (48): 46073–8. doi:10.1074/jbc.M209560200. PMID 12354755.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagarkatti R, Ghosh B (2003). "Identification of single-nucleotide and repeat polymorphisms in two candidate genes, interleukin 4 receptor (IL4RA) and signal transducer and activator of transcription protein 6 (STAT6), for Th2-mediated diseases.". J. Hum. Genet. 47 (12): 684–7. doi:10.1007/s100380200105. PMID 12522691.
He JQ, Connett JE, Anthonisen NR, Sandford AJ (2003). "Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers.". Am. J. Respir. Cell Mol. Biol. 28 (3): 379–85. doi:10.1165/rcmb.4885. PMID 12594065.
Niu Y, Murata T, Watanabe K, et al. (2003). "MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation.". FEBS Lett. 550 (1-3): 139–43. doi:10.1016/S0014-5793(03)00860-3. PMID 12935900.
Wongpiyabovorn J, Suto H, Ushio H, et al. (2004). "Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis.". J. Dermatol. Sci. 33 (1): 31–40. doi:10.1016/S0923-1811(03)00148-8. PMID 14527737.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Arima K, Sato K, Tanaka G, et al. (2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors.". J. Biol. Chem. 280 (26): 24915–22. doi:10.1074/jbc.M502571200. PMID 15870068.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kaur D, Hollins F, Woodman L, et al. (2007). "Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression.". Allergy 61 (9): 1047–53. doi:10.1111/j.1398-9995.2006.01139.x. PMID 16918506.

External links

IL13RA1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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Interleukin 13 receptor, alpha 1

See also

References

Further reading

External links