CD160

CD160 molecule
Identifiers
Symbols	CD160 ; BY55; NK1; NK28
External IDs	OMIM: 604463 MGI: 1860383 HomoloGene: 5122 GeneCards: CD160 Gene
Gene ontology Molecular function • receptor activity • receptor binding • protein binding • MHC class I receptor activity Cellular component • plasma membrane • anchored component of plasma membrane Biological process • cellular defense response • cell surface receptor signaling pathway • cell proliferation • regulation of immune response • defense response to Gram-negative bacterium Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11126	54215
Ensembl	ENSG00000117281	ENSMUSG00000038304
UniProt	O95971	O88875
RefSeq (mRNA)	NM_007053	NM_001163496
RefSeq (protein)	NP_008984	NP_001156968
Location (UCSC)	Chr 1: 145.72 – 145.74 Mb	Chr 3: 96.8 – 96.83 Mb
PubMed search

CD160 antigen is a protein that in humans is encoded by the CD160 gene.^[1][2][3]

CD160 is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.^[3]

Clinical significance

CD160 as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.

Related gene problems

• TAR syndrome^[4]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

See also

• Cluster of differentiation

References

1. Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ (Oct 1998). "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes". J Immunol 161 (6): 2780–90. PMID 9743336.
2. Agrawal S, Marquet J, Freeman GJ, Tawab A, Bouteiller PL, Roth P, Bolton W, Ogg G, Boumsell L, Bensussan A (Apr 1999). "Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells". J Immunol 162 (3): 1223–6. PMID 9973372.
3. "Entrez Gene: CD160 CD160 molecule".
4. Klopocki E, Schulze H, Strauss G; et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading

• Bensussan A, Gluckman E, el Marsafy S; et al. (1994). "BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity.". Proc. Natl. Acad. Sci. U.S.A. 91 (19): 9136–40. doi:10.1073/pnas.91.19.9136. PMC 44762. PMID 8090781.
• Nikolova M, Marie-Cardine A, Boumsell L, Bensussan A (2002). "BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.". Int. Immunol. 14 (5): 445–51. doi:10.1093/intimm/14.5.445. PMID 11978774.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tanaka J, Toubai T, Tsutsumi Y; et al. (2004). "Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells.". Blood 104 (3): 768–74. doi:10.1182/blood-2003-11-3870. PMID 15073036.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barakonyi A, Rabot M, Marie-Cardine A; et al. (2004). "Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset.". J. Immunol. 173 (9): 5349–54. doi:10.4049/jimmunol.173.9.5349. PMID 15494480.
• Abecassis S, Giustiniani J, Meyer N; et al. (2007). "Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation.". J. Invest. Dermatol. 127 (5): 1161–6. doi:10.1038/sj.jid.5700680. PMID 17218942.
• Giustiniani J, Marie-Cardine A, Bensussan A (2007). "A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity.". J. Immunol. 178 (3): 1293–300. doi:10.4049/jimmunol.178.3.1293. PMID 17237375.

External links

• CD160 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

Skin Research Center lab Hopital St Louis, Paris (France) Dir. Dr. A. Bensussan