TNFRSF12A

Tumor necrosis factor receptor superfamily, member 12A
Rendering based on PDB 2EQP​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2EQP​, 2KMZ​, 2RPJ​
Identifiers
Symbols	TNFRSF12A ; CD266; FN14; TWEAKR
External IDs	OMIM: 605914 MGI: 1351484 HomoloGene: 8451 IUPHAR: 1884 GeneCards: TNFRSF12A Gene
Gene ontology Molecular function • protein binding Cellular component • ruffle • plasma membrane • cell surface • integral component of membrane Biological process • angiogenesis • substrate-dependent cell migration, cell attachment to substrate • positive regulation of apoptotic process • regulation of angiogenesis • positive regulation of axon extension • regulation of wound healing • extrinsic apoptotic signaling pathway • positive regulation of extrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51330	27279
Ensembl	ENSG00000006327	ENSMUSG00000023905
UniProt	Q9NP84	Q9CR75
RefSeq (mRNA)	NM_016639	NM_001161746
RefSeq (protein)	NP_057723	NP_001155218
Location (UCSC)	Chr 16: 3.02 – 3.02 Mb	Chr 17: 23.68 – 23.68 Mb
PubMed search

Tumor necrosis factor receptor superfamily member 12A also known as the Tweak-receptor (TweakR) is a protein that in humans is encoded by the TNFRSF12A gene.^[1][2][3]

Clinical significance

NFAT1 regulates the expression of TWEAKR (this protein) and its ligand TWEAK with lipocalin 2 to increase breast cancer cell invasion.^[4]

References

1. Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, Peifley KA, Winkles JA (Jun 2000). "The Fn14 Immediate-Early Response Gene Is Induced During Liver Regeneration and Highly Expressed in Both Human and Murine Hepatocellular Carcinomas". Am J Pathol 156 (4): 1253–61. doi:10.1016/S0002-9440(10)64996-6. PMC 1876890. PMID 10751351.
2. Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, Winkles JA (Jan 2000). "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration". J Biol Chem 274 (46): 33166–76. doi:10.1074/jbc.274.46.33166. PMID 10551889.
3. "Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A".
4. Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S (October 2012). "Lipocalin 2, the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion". J. Cell. Sci. 125 (Pt 19): 4475–86. doi:10.1242/jcs.099879. PMID 22767506.

Further reading

• Campbell S, Michaelson J, Burkly L, Putterman C (2006). "The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity". Front. Biosci. 9: 2273–84. doi:10.2741/1395. PMID 15353286.
• Wiley SR, Cassiano L, Lofton T, et al. (2001). "A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis". Immunity 15 (5): 837–46. doi:10.1016/S1074-7613(01)00232-1. PMID 11728344.
• Harada N, Nakayama M, Nakano H, et al. (2003). "Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells". Biochem. Biophys. Res. Commun. 299 (3): 488–93. doi:10.1016/S0006-291X(02)02670-0. PMID 12445828.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Ishidoh K, Kojima Y, et al. (2003). "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death". J. Immunol. 170 (1): 341–8. doi:10.4049/jimmunol.170.1.341. PMID 12496418.
• Tran NL, McDonough WS, Donohue PJ, et al. (2003). "The Human Fn14 Receptor Gene Is Up-Regulated in Migrating Glioma Cells in Vitro and Overexpressed in Advanced Glial Tumors". Am. J. Pathol. 162 (4): 1313–21. doi:10.1016/S0002-9440(10)63927-2. PMC 1851233. PMID 12651623.
• Tanabe K, Bonilla I, Winkles JA, Strittmatter SM (2003). "Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth". J. Neurosci. 23 (29): 9675–86. PMID 14573547.
• Jin L, Nakao A, Nakayama M, et al. (2004). "Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes". J. Invest. Dermatol. 122 (5): 1175–9. doi:10.1111/j.0022-202X.2004.22419.x. PMID 15140220.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tran NL, McDonough WS, Savitch BA, et al. (2005). "The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression". J. Biol. Chem. 280 (5): 3483–92. doi:10.1074/jbc.M409906200. PMID 15611130.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Chacón MR, Richart C, Gómez JM, et al. (2006). "Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity". Cytokine 33 (3): 129–37. doi:10.1016/j.cyto.2005.12.005. PMID 16503147.
• Brown SA, Hanscom HN, Vu H, et al. (2006). "TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules". Biochem. J. 397 (2): 297–304. doi:10.1042/BJ20051362. PMC 1513280. PMID 16526941.
• Muñoz-García B, Martín-Ventura JL, Martínez E, et al. (2006). "Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin". Stroke 37 (8): 2044–53. doi:10.1161/01.STR.0000230648.00027.00. PMID 16809572.
• Tran NL, McDonough WS, Savitch BA, et al. (2007). "Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome". Cancer Res. 66 (19): 9535–42. doi:10.1158/0008-5472.CAN-06-0418. PMID 17018610.
• Girgenrath M, Weng S, Kostek CA, et al. (2007). "TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration". EMBO J. 25 (24): 5826–39. doi:10.1038/sj.emboj.7601441. PMC 1698888. PMID 17124496.
• Dogra C, Hall SL, Wedhas N, et al. (2007). "Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis". J. Biol. Chem. 282 (20): 15000–10. doi:10.1074/jbc.M608668200. PMID 17383968.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.