CCRL1

Atypical chemokine receptor 4
Identifiers
Symbols	ACKR4 ; CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11; CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1
External IDs	OMIM: 606065 MGI: 2181676 HomoloGene: 49474 IUPHAR: 315 ChEMBL: 2917 GeneCards: ACKR4 Gene
Gene ontology Molecular function • chemokine receptor activity • scavenger receptor activity • protein binding • chemokine binding Cellular component • early endosome • plasma membrane • integral component of plasma membrane • recycling endosome Biological process • receptor-mediated endocytosis • chemotaxis • immune response • G-protein coupled receptor signaling pathway • chemokine-mediated signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51554	252837
Ensembl	ENSG00000129048	ENSMUSG00000079355
UniProt	Q9NPB9	Q924I3
RefSeq (mRNA)	NM_016557	NM_145700
RefSeq (protein)	NP_057641	NP_663746
Location (UCSC)	Chr 3: 132.6 – 132.62 Mb	Chr 9: 104.08 – 104.13 Mb
PubMed search

C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.^[1][2]

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.^[2]

References

1. Khoja H, Wang G, Ng CT, Tucker J, Brown T, Shyamala V (May 2000). "Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart". Gene 246 (1–2): 229–38. doi:10.1016/S0378-1119(00)00076-7. PMID 10767544.
2. "Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bacon KB, Schall TJ, Dairaghi DJ (1998). "RANTES activation of phospholipase D in Jurkat T cells: requirement of GTP-binding proteins ARF and RhoA". J. Immunol. 160 (4): 1894–900. PMID 9469451.
• Gosling J, Dairaghi DJ, Wang Y; et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
• Schweickart VL, Epp A, Raport CJ, Gray PW (2000). "CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines". J. Biol. Chem. 275 (13): 9550–6. doi:10.1074/jbc.275.13.9550. PMID 10734104.
• Schweickart VL, Epp A, Raport CJ, Gray PW (2001). "CCR11 is a functional receptor for the monocyte chemoaattractant protein family of chemokines". The Journal of Biological Chemistry 276 (1): 856. PMID 11134065.
• Townson JR, Nibbs RJ (2002). "Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR". Eur. J. Immunol. 32 (5): 1230–41. doi:10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L. PMID 11981810.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Comerford I, Milasta S, Morrow V; et al. (2006). "The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro". Eur. J. Immunol. 36 (7): 1904–16. doi:10.1002/eji.200535716. PMID 16791897.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.