XCR1

Chemokine (C motif) receptor 1
Identifiers
Symbols	XCR1 ; CCXCR1; GPR5
External IDs	OMIM: 600552 MGI: 1346338 HomoloGene: 21095 IUPHAR: 75 ChEMBL: 4339 GeneCards: XCR1 Gene
Gene ontology Molecular function • chemokine receptor activity Cellular component • cytosol • plasma membrane • integral component of plasma membrane Biological process • chemotaxis • inflammatory response • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • positive regulation of cytosolic calcium ion concentration • release of sequestered calcium ion into cytosol • chemokine-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2829	23832
Ensembl	ENSG00000173578	ENSMUSG00000060509
UniProt	P46094	Q9R0M1
RefSeq (mRNA)	NM_001024644	NM_011798
RefSeq (protein)	NP_001019815	NP_035928
Location (UCSC)	Chr 3: 46.02 – 46.03 Mb	Chr 9: 123.85 – 123.86 Mb
PubMed search

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[1]

References

1. "Entrez Gene: XCR1 chemokine (C motif) receptor 1".

External links

• "Chemokine Receptors: XCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Maghazachi AA (1999). "Intracellular signalling pathways induced by chemokines in natural killer cells.". Cell. Signal. 11 (6): 385–90. doi:10.1016/S0898-6568(99)00008-X. PMID 10400311.
• Gao JL, Kuhns DB, Tiffany HL, et al. (1993). "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.". J. Exp. Med. 177 (5): 1421–7. doi:10.1084/jem.177.5.1421. PMC 2191019. PMID 7683036.
• Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors.". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990.
• Yoshida T, Imai T, Kakizaki M, et al. (1998). "Identification of single C motif-1/lymphotactin receptor XCR1.". J. Biol. Chem. 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.
• Shan L, Qiao X, Oldham E, et al. (2000). "Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1.". Biochem. Biophys. Res. Commun. 268 (3): 938–41. doi:10.1006/bbrc.2000.2235. PMID 10679309.
• Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.". Cytogenet. Cell Genet. 87 (3-4): 265–8. doi:10.1159/000015443. PMID 10702689.
• Kurt RA, Bauck M, Harma S, et al. (2001). "Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo.". Cell. Immunol. 209 (2): 83–8. doi:10.1006/cimm.2001.1790. PMID 11446740.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shinkai H, Morozumi T, Toki D, et al. (2005). "Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1.". Gene 349: 55–66. doi:10.1016/j.gene.2004.10.017. PMID 15777643.
• Lüttichau HR, Johnsen AH, Jurlander J, et al. (2007). "Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3.". J. Biol. Chem. 282 (24): 17794–805. doi:10.1074/jbc.M702001200. PMID 17403668.

External links

• XCR1 receptor, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.