IL17RA

Interleukin 17 receptor A
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3JVF​, 4HSA​, 4NUX​
Identifiers
Symbols	IL17RA ; CANDF5; CD217; CDw217; IL-17RA; IL17R; hIL-17R
External IDs	OMIM: 605461 MGI: 107399 HomoloGene: 7378 IUPHAR: 1738 GeneCards: IL17RA Gene
Gene ontology Molecular function • protein binding • interleukin-17 receptor activity Cellular component • extracellular region • integral component of plasma membrane Biological process • cell surface receptor signaling pathway • cytokine-mediated signaling pathway • positive regulation of interleukin-23 production • fibroblast activation • positive regulation of cytokine production involved in inflammatory response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23765	16172
Ensembl	ENSG00000177663	ENSMUSG00000002897
UniProt	Q96F46	Q60943
RefSeq (mRNA)	NM_001289905	NM_008359
RefSeq (protein)	NP_001276834	NP_032385
Location (UCSC)	Chr 22: 17.08 – 17.12 Mb	Chr 6: 120.46 – 120.48 Mb
PubMed search

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.^[1]

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.^[1]

See also

• Interleukin-17 receptor

References

1. "Entrez Gene: IL17RA interleukin 17 receptor A".

Further reading

• Yao Z, Spriggs MK, Derry JM, et al. (1998). "Molecular characterization of the human interleukin (IL)-17 receptor". Cytokine 9 (11): 794–800. doi:10.1006/cyto.1997.0240. PMID 9367539.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Honorati MC, Meliconi R, Pulsatelli L, et al. (2001). "High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients". Rheumatology (Oxford) 40 (5): 522–7. doi:10.1093/rheumatology/40.5.522. PMID 11371660.
• Footz TK, Brinkman-Mills P, Banting GS, et al. (2001). "Analysis of the Cat Eye Syndrome Critical Region in Humans and the Region of Conserved Synteny in Mice: A Search for Candidate Genes at or near the Human Chromosome 22 Pericentromere". Genome Res. 11 (6): 1053–70. doi:10.1101/gr.154901. PMC 311098. PMID 11381032.
• Haudenschild D, Moseley T, Rose L, Reddi AH (2002). "Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer". J. Biol. Chem. 277 (6): 4309–16. doi:10.1074/jbc.M109372200. PMID 11706037.
• Kehlen A, Thiele K, Riemann D, Langner J (2002). "Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis". Clin. Exp. Immunol. 127 (3): 539–46. doi:10.1046/j.1365-2249.2002.01782.x. PMC 1906300. PMID 11966773.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Steiner GE, Newman ME, Paikl D, et al. (2003). "Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate". Prostate 56 (3): 171–82. doi:10.1002/pros.10238. PMID 12772186.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• McAllister F, Henry A, Kreindler JL, et al. (2005). "Role of IL-17A, IL-17F, and the IL-17 Receptor in Regulating Growth-Related Oncogene-α and Granulocyte Colony-Stimulating Factor in Bronchial Epithelium: Implications for Airway Inflammation in Cystic Fibrosis". J. Immunol. 175 (1): 404–12. doi:10.4049/jimmunol.175.1.404. PMC 2849297. PMID 15972674.
• Pongcharoen S, Niumsup P, Sanguansermsri D, et al. (2006). "The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells". Am. J. Reprod. Immunol. 55 (4): 291–300. doi:10.1111/j.1600-0897.2006.00366.x. PMID 16533341.
• Toy D, Kugler D, Wolfson M, et al. (2006). "Cutting edge: interleukin 17 signals through a heteromeric receptor complex". J. Immunol. 177 (1): 36–9. doi:10.4049/jimmunol.177.1.36. PMID 16785495.
• Wang X, Dong Z, Zhu DD, Guan B (2006). "Expression profile of immune-associated genes in nasal polyps". Ann. Otol. Rhinol. Laryngol. 115 (6): 450–6. PMID 16805377.
• Rong Z, Cheng L, Ren Y, et al. (2007). "Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6". Cell. Signal. 19 (7): 1514–20. doi:10.1016/j.cellsig.2007.01.025. PMID 17346928.
• Maitra A, Shen F, Hanel W, et al. (2007). "Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression". Proc. Natl. Acad. Sci. U.S.A. 104 (18): 7506–11. doi:10.1073/pnas.0611589104. PMC 1863505. PMID 17456598.

External links

• IL17RA protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.