CD164

CD164 molecule, sialomucin
Identifiers
Symbols	CD164 ; MGC-24; MUC-24; endolyn
External IDs	OMIM: 603356 MGI: 1859568 HomoloGene: 38129 GeneCards: CD164 Gene
Gene ontology Molecular function • protein binding Cellular component • extracellular region • lysosome • lysosomal membrane • endosome • plasma membrane • integral component of plasma membrane • endosome membrane Biological process • immune response • cell adhesion • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • negative regulation of cell adhesion • signal transduction • multicellular organismal development • muscle organ development • negative regulation of cell proliferation • hemopoiesis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8763	53599
Ensembl	ENSG00000135535	ENSMUSG00000019818
UniProt	Q04900	Q9R0L9
RefSeq (mRNA)	NM_001142401	NM_016898
RefSeq (protein)	NP_001135873	NP_058594
Location (UCSC)	Chr 6: 109.37 – 109.38 Mb	Chr 10: 41.52 – 41.53 Mb
PubMed search

Sialomucin core protein 24 also known as endolyn or CD164 (cluster of differentiation 164) is a protein that in humans is encoded by the CD164 gene.^[1][2] CD164 functions as a cell adhesion molecule.

Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play two key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor.^[1]

References

1. Watt SM, Bühring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, Butler LH (August 1998). "CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21". Blood 92 (3): 849–66. PMID 9680353.
2. Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ (October 1998). "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis". Blood 92 (8): 2613–28. PMID 9763543.

Further reading

• Zannettino AC (2001). "CD164.". J. Biol. Regul. Homeost. Agents 15 (4): 394–6. PMID 11862985.
• Masuzawa Y, Miyauchi T, Hamanoue M; et al. (1992). "A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression.". J. Biochem. 112 (5): 609–15. PMID 1478919.
• Zhou GQ, Zhang Y, Ferguson DJ; et al. (2006). "The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation.". J. Cell. Biochem. 99 (5): 1380–96. doi:10.1002/jcb.20965. PMID 16924678.
• Chan JY, Lee-Prudhoe JE, Jorgensen B; et al. (2001). "Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn.". J. Biol. Chem. 276 (3): 2139–52. doi:10.1074/jbc.M007965200. PMID 11027692.
• Ganesh SK, Zakai NA, van Rooij FJ; et al. (2009). "Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium". Nat. Genet. 41 (11): 1191–8. doi:10.1038/ng.466. PMC 2778265. PMID 19862010.
• Barbe L, Lundberg E, Oksvold P; et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell Proteomics 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
• Kurosawa N, Kanemitsu Y, Matsui T; et al. (1999). "Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164". Eur. J. Biochem. 265 (1): 466–72. doi:10.1046/j.1432-1327.1999.00777.x. PMID 10491205.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Doyonnas R, Yi-Hsin Chan J, Butler LH; et al. (2000). "CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor". J. Immunol. 165 (2): 840–51. doi:10.4049/jimmunol.165.2.840. PMID 10878358.
• Gudbjartsson DF, Walters GB, Thorleifsson G; et al. (2008). "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Oh JH, Yang JO, Hahn Y; et al. (2005). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Havens AM, Jung Y, Sun YX; et al. (2006). "The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis". BMC Cancer 6: 195. doi:10.1186/1471-2407-6-195. PMC 1557671. PMID 16859559.
• Forde S, Tye BJ, Newey SE; et al. (2007). "Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells". Blood 109 (5): 1825–33. doi:10.1182/blood-2006-05-023028. PMID 17077324.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hennersdorf F, Florian S, Jakob A; et al. (2005). "Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation". Cell Res. 15 (5): 325–35. doi:10.1038/sj.cr.7290301. PMID 15916720.

External links

• CD164 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)