CDH17

Cadherin 17, LI cadherin (liver-intestine)
Identifiers
Symbols	CDH17 ; CDH16; HPT-1; HPT1
External IDs	OMIM: 603017 MGI: 1095414 HomoloGene: 56859 GeneCards: CDH17 Gene
Gene ontology Molecular function • transporter activity • proton-dependent oligopeptide secondary active transmembrane transporter activity • calcium ion binding Cellular component • plasma membrane • integral component of membrane • basolateral plasma membrane Biological process • transport • oligopeptide transport • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • cell junction assembly • adherens junction organization • oligopeptide transmembrane transport • cell-cell junction organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1015	12557
Ensembl	ENSG00000079112	ENSMUSG00000028217
UniProt	Q12864	Q9R100
RefSeq (mRNA)	NM_001144663	NM_019753
RefSeq (protein)	NP_001138135	NP_062727
Location (UCSC)	Chr 8: 94.13 – 94.22 Mb	Chr 4: 11.76 – 11.82 Mb
PubMed search

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.^[1][2][3]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.^[3]

References

1. Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
2. Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
3. "Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)".

Further reading

• Gessner R, Tauber R (2001). "Intestinal cell adhesion molecules. Liver-intestine cadherin.". Ann. N. Y. Acad. Sci. 915: 136–43. doi:10.1111/j.1749-6632.2000.tb05236.x. PMID 11193569.
• Gilston A (1978). "Reducing the hazard of disconnected tubes.". Anaesthesia 32 (9): 922. doi:10.1111/j.1365-2044.1977.tb10133.x. PMID 603017.
• Dantzig AH, Hoskins JA, Tabas LB; et al. (1994). "Association of intestinal peptide transport with a protein related to the cadherin superfamily.". Science 264 (5157): 430–3. doi:10.1126/science.8153632. PMID 8153632.
• Suzuki Y, Tsunoda T, Sese J; et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467.
• Grötzinger C, Kneifel J, Patschan D; et al. (2001). "LI-cadherin: a marker of gastric metaplasia and neoplasia.". Gut 49 (1): 73–81. doi:10.1136/gut.49.1.73. PMC 1728355. PMID 11413113.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Takamura M, Sakamoto M, Ino Y; et al. (2003). "Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas.". Cancer Sci. 94 (5): 425–30. doi:10.1111/j.1349-7006.2003.tb01459.x. PMID 12824888.
• Wendeler MW, Praus M, Jung R; et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin.". Exp. Cell Res. 294 (2): 345–55. doi:10.1016/j.yexcr.2003.11.022. PMID 15023525.
• Ko S, Chu KM, Luk JM; et al. (2004). "Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis.". Biochem. Biophys. Res. Commun. 319 (2): 562–8. doi:10.1016/j.bbrc.2004.04.197. PMID 15178443.
• Takamura M, Ichida T, Matsuda Y; et al. (2004). "Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma.". Cancer Lett. 212 (2): 253–9. doi:10.1016/j.canlet.2004.03.016. PMID 15279905.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Wang XQ, Luk JM, Leung PP; et al. (2005). "Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma.". Clin. Cancer Res. 11 (2 Pt 1): 483–9. PMID 15701831.
• Wang XQ, Luk JM, Garcia-Barcelo M; et al. (2007). "Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma.". Clin. Cancer Res. 12 (17): 5248–52. doi:10.1158/1078-0432.CCR-06-0558. PMID 16951245.

External links

• CDH17 human gene location in the UCSC Genome Browser.
• CDH17 human gene details in the UCSC Genome Browser.