CDH6

Cadherin 6, type 2, K-cadherin (fetal kidney)
Identifiers
Symbols	CDH6 ; CAD6; KCAD
External IDs	OMIM: 603007 MGI: 107435 HomoloGene: 21027 GeneCards: CDH6 Gene
Gene ontology Molecular function • calcium ion binding Cellular component • plasma membrane • integral component of membrane • extracellular exosome Biological process • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules • cell junction assembly • adherens junction organization • cell-cell junction organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1004	12563
Ensembl	ENSG00000113361	ENSMUSG00000039385
UniProt	P55285	P97326
RefSeq (mRNA)	NM_004932	NM_007666
RefSeq (protein)	NP_004923	NP_031692
Location (UCSC)	Chr 5: 31.19 – 31.33 Mb	Chr 15: 13.03 – 13.17 Mb
PubMed search

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.^[1][2][3]

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.^[3]

References

1. Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S (Jun 1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells". Cancer Res 55 (10): 2206–11. PMID 7743525.
2. Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
3. "Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)".

Further reading

• MacCalman CD, Getsios S, Chen GT (1998). "Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentation.". Am. J. Reprod. Immunol. 39 (2): 96–107. doi:10.1111/j.1600-0897.1998.tb00341.x. PMID 9506208.
• Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
• Paul R, Ewing CM, Robinson JC; et al. (1997). "Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma.". Cancer Res. 57 (13): 2741–8. PMID 9205085.
• Getsios S, Chen GT, Stephenson MD; et al. (1998). "Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium.". Dev. Dyn. 211 (3): 238–47. doi:10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I. PMID 9520111.
• Kremmidiotis G, Baker E, Crawford J; et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
• Shimoyama Y, Takeda H, Yoshihara S; et al. (1999). "Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin.". J. Biol. Chem. 274 (17): 11987–94. doi:10.1074/jbc.274.17.11987. PMID 10207020.
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• CDH6 human gene location in the UCSC Genome Browser.
• CDH6 human gene details in the UCSC Genome Browser.