CDH15

Cadherin 15, type 1, M-cadherin (myotubule)
Identifiers
Symbols	CDH15 ; CDH14; CDH3; CDHM; MCAD; MRD3
External IDs	OMIM: 114019 MGI: 106672 HomoloGene: 3622 GeneCards: CDH15 Gene
Gene ontology Molecular function • calcium ion binding • protein binding Cellular component • plasma membrane • caveola • integral component of membrane • neuromuscular junction • extracellular exosome Biological process • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules • cell junction assembly • adherens junction organization • muscle cell differentiation • cell-cell junction organization • positive regulation of muscle cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1013	12555
Ensembl	ENSG00000129910	ENSMUSG00000031962
UniProt	P55291	P33146
RefSeq (mRNA)	NM_004933	NM_007662
RefSeq (protein)	NP_004924	NP_031688
Location (UCSC)	Chr 16: 89.17 – 89.2 Mb	Chr 8: 122.85 – 122.87 Mb
PubMed search

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.^[1][2]

Function

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.^[2]

Interactions

CDH15 has been shown to interact with ARVCF.^[3]

References

1. Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
2. "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)".
3. Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (November 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell. Sci. 113 (22): 4121–35. PMID 11058098.

Further reading

• Donalies M, Cramer M, Ringwald M, Starzinski-Powitz A (1991). "Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells.". Proc. Natl. Acad. Sci. U.S.A. 88 (18): 8024–8. doi:10.1073/pnas.88.18.8024. PMC 52438. PMID 1840697.
• Bornemann A, Schmalbruch H (1994). "Immunocytochemistry of M-cadherin in mature and regenerating rat muscle.". Anat. Rec. 239 (2): 119–25. doi:10.1002/ar.1092390202. PMID 8059975.
• Shibata T, Shimoyama Y, Gotoh M, Hirohashi S (1997). "Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning.". J. Biol. Chem. 272 (8): 5236–40. doi:10.1074/jbc.272.8.5236. PMID 9030594.
• Kuch C, Winnekendonk D, Butz S, Unvericht U, Kemler R, Starzinski-Powitz A (1997). "M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells.". Exp. Cell Res. 232 (2): 331–8. doi:10.1006/excr.1997.3519. PMID 9168809.
• Shimoyama Y, Shibata T, Kitajima M, Hirohashi S (1998). "Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin.". J. Biol. Chem. 273 (16): 10011–8. doi:10.1074/jbc.273.16.10011. PMID 9545347.
• Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
• Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (2001). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions.". J. Cell. Sci. 113 (22): 4121–35. PMID 11058098.
• Meigs TE, Fields TA, McKee DD, Casey PJ (2001). "Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 519–24. doi:10.1073/pnas.021350998. PMC 14619. PMID 11136230.
• Hollnagel A, Grund C, Franke WW, Arnold HH (2002). "The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration.". Mol. Cell. Biol. 22 (13): 4760–70. doi:10.1128/MCB.22.13.4760-4770.2002. PMC 133893. PMID 12052883.
• Kang JS, Feinleib JL, Knox S, Ketteringham MA, Krauss RS (2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 3989–94. doi:10.1073/pnas.0736565100. PMC 153035. PMID 12634428.

External links

• CDH15 human gene location in the UCSC Genome Browser.
• CDH15 human gene details in the UCSC Genome Browser.